Gene Symbol | KLF11 |
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Entrez Gene | 8462 |
Alt Symbol | FKLF, FKLF1, MODY7, TIEG2, Tieg3 |
Species | Human |
Gene Type | protein-coding |
Description | Kruppel-like factor 11 |
Other Description | Krueppel-like factor 11|TGFB-inducible early growth response protein 2|TIEG-2|transforming growth factor-beta-inducible early growth response protein 2 |
Swissprots | Q9EPF4 O14901 B4DZE7 |
Accessions | AAX93098 CAH23425 CAH33945 EAX00972 O14901 AF028008 AAC61880 AF272830 AAF75793 AI183650 AI755210 AJ275989 CAC06699 AK002186 AK289816 BAF82505 AK302880 BAG64059 AK315345 BAG37743 AK316439 BAH14810 BC063286 AAH63286 BC069383 AAH69383 BC074922 AAH74922 BG701929 BM548792 BQ881155 CB990375 XM_005246179 XP_005246236 NM_001177716 NP_001171187 NM_001177718 NP_001171189 NM_003597 NP_003588 |
Function | Transcription factor. Activates the epsilon- and gamma- globin gene promoters and, to a much lower degree, the beta-globin gene and represses promoters containing SP1-like binding inhibiting cell growth. Represses transcription of SMAD7 which enhances TGF-beta signaling. Induces apoptosis. {ECO:0000269|PubMed:10207080}. |
Subcellular Location | Nucleus. |
Tissue Specificity | Ubiquitous. Higher expression in erythroid cells. {ECO:0000269|PubMed:10207080}. |
TIEG2 CRISPR/Cas9 KO Plasmid (h) - sc-407645 from Santa Cruz Biotechnology
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TIEG2 HDR Plasmid (h) - sc-407645-HDR from Santa Cruz Biotechnology
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TIEG2 Double Nickase Plasmid (h) - sc-407645-NIC from Santa Cruz Biotechnology
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TIEG2 Double Nickase Plasmid (h2) - sc-407645-NIC-2 from Santa Cruz Biotechnology
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TIEG2 CRISPR Activation Plasmid (h) - sc-407645-ACT from Santa Cruz Biotechnology
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TIEG2 CRISPR Activation Plasmid (h2) - sc-407645-ACT-2 from Santa Cruz Biotechnology
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TIEG2 Lentiviral Activation Particles (h) - sc-407645-LAC from Santa Cruz Biotechnology
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TIEG2 Lentiviral Activation Particles (h2) - sc-407645-LAC-2 from Santa Cruz Biotechnology
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TIEG2 siRNA (h) - sc-38546 from Santa Cruz Biotechnology
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TIEG2 shRNA Plasmid (h) - sc-38546-SH from Santa Cruz Biotechnology
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TIEG2 shRNA (h) Lentiviral Particles - sc-38546-V from Santa Cruz Biotechnology
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KLF11 RNAi - H00008462-R01 from Novus Biologicals
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MISSION® esiRNA - EHU015881 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN11245 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11245 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR11282 from Sigma-Aldrich
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KLF11 siRNA (Human) - CRH5548 from Cohesion Biosciences
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shRNA set against Human KLF11 (NM_003597.4) - SHH325727 from Creative biogene
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Human KLF11 siRNA - orb266050 from Biorbyt
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KLF11 shRNA Plasmid (Human) - CHH5548 from Cohesion Biosciences
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KLF11 miRNA 3'UTR clone - MiUTR1H-05354 from Creative biogene
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