Gene Symbol | APOC2 |
---|---|
Entrez Gene | 344 |
Alt Symbol | APO-CII, APOC-II |
Species | Human |
Gene Type | protein-coding |
Description | apolipoprotein C-II |
Other Description | apolipoprotein C2 |
Swissprots | Q9UDE3 Q9BS39 P02655 C0JYY4 Q9UNK3 |
Accessions | AAA98743 AAB59380 AAQ91814 ACN81313 CAA28798 EAW57311 EAW57312 EAW57313 P02655 AA883870 AF113884 AAD28193 AV694494 BC005348 AAH05348 BC065270 AAH65270 BT006708 AAP35354 BU596546 EU832654 ACE87745 EU832732 ACE87064 M29844 AAA51743 X00568 CAA25234 NM_000483 NP_000474 |
Function | Component of chylomicrons, very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL) in plasma. Plays an important role in lipoprotein metabolism as an activator of lipoprotein lipase. Both proapolipoprotein C-II and apolipoprotein C-II can activate lipoprotein lipase. In normolipidemic individuals, it is mainly distributed in the HDL, whereas in hypertriglyceridemic individuals, predominantly found in the VLDL and LDL. {ECO:0000269|PubMed:2209608, ECO:0000303|PubMed:22304839}. |
Subcellular Location | Secreted {ECO:0000269|PubMed:3525527}. |
Tissue Specificity | Liver and intestine. {ECO:0000269|PubMed:6546757}. |
apoC-II CRISPR/Cas9 KO Plasmid (h) - sc-406468 from Santa Cruz Biotechnology
|
||||||||
apoC-II HDR Plasmid (h) - sc-406468-HDR from Santa Cruz Biotechnology
|
||||||||
apoC-II Double Nickase Plasmid (h) - sc-406468-NIC from Santa Cruz Biotechnology
|
||||||||
apoC-II Double Nickase Plasmid (h2) - sc-406468-NIC-2 from Santa Cruz Biotechnology
|
||||||||
apoC-II CRISPR Activation Plasmid (h) - sc-406468-ACT from Santa Cruz Biotechnology
|
||||||||
apoC-II CRISPR Activation Plasmid (h2) - sc-406468-ACT-2 from Santa Cruz Biotechnology
|
||||||||
apoC-II Lentiviral Activation Particles (h) - sc-406468-LAC from Santa Cruz Biotechnology
|
||||||||
apoC-II Lentiviral Activation Particles (h2) - sc-406468-LAC-2 from Santa Cruz Biotechnology
|
||||||||
apoC-II siRNA (h) - sc-41184 from Santa Cruz Biotechnology
|
||||||||
apoC-II shRNA Plasmid (h) - sc-41184-SH from Santa Cruz Biotechnology
|
||||||||
apoC-II shRNA (h) Lentiviral Particles - sc-41184-V from Santa Cruz Biotechnology
|
||||||||
MISSION® esiRNA - EHU115791 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN3343 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3343 from Sigma-Aldrich
|
||||||||
MISSION® 3′UTR Lenti GoClone™ - HUTR02168 from Sigma-Aldrich
|
||||||||
APOC2 siRNA (Human) - CRH0242 from Cohesion Biosciences
|
||||||||
Apolipoprotein C-II/ApoC2 RNAi - H00000344-R01 from Novus Biologicals
|
||||||||
APOC2 - MBS8204128 from MyBioSource
|
||||||||
shRNA set against Human APOC2 (NM_000483.4) - SHH238494 from Creative biogene
|
||||||||
Human APOC2 siRNA - orb260744 from Biorbyt
|
||||||||
APOC2 shRNA Plasmid (Human) - CHH0242 from Cohesion Biosciences
|
||||||||
APOC2 miRNA 3'UTR clone - MiUTR3H-09726 from Creative biogene
|