PTTG1

Gene Symbol	PTTG1
Entrez Gene	9232
Alt Symbol	EAP1, HPTTG, PTTG, TUTR1
Species	Human
Gene Type	protein-coding
Description	pituitary tumor-transforming 1
Other Description	ESP1-associated protein 1|pituitary tumor-transforming gene 1 protein|securin|tumor-transforming protein 1
Swissprots	O95997
Accessions	AAF06995 BAH69081 BAH69082 CAY55983 EAW61551 EAW61552 EAW61553 O95997 AF062649 AAC69752 AF075242 AAD19335 AF095287 AAC64409 AJ223953 CAA11683 AK312209 BAG35142 BC026003 BC101834 AAI01835 BC108894 AAI08895 BC108895 AAI08896 BC112071 AAI12072 BC113842 AAI13843 BC113896 AAI13897 BC128193 AAI28194 BC128194 AAI28195 BI827526 BM990391 BU182149 CR457135 CAG33416 CR541685 CAG46486 HY006026 NM_001282382 NP_001269311 NM_001282383 NP_001269312 NM_004219 NP_004210
Function	Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of TP53. The negative regulation of TP53 may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation. {ECO:0000269|PubMed:10411507, ECO:0000269|PubMed:11238996, ECO:0000269|PubMed:11371342, ECO:0000269|PubMed:1
Subcellular Location	Cytoplasm. Nucleus.
Tissue Specificity	Expressed at low level in most tissues, except in adult testis, where it is highly expressed. Overexpressed in many patients suffering from pituitary adenomas, primary epithelial neoplasias, and esophageal cancer. {ECO:0000269|PubMed:9811450}.
Top Pathways	Cell cycle, Oocyte meiosis, HTLV-I infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Securin / PTTG1 ELISA Kit (Cell-Based ELISA) - LS-F3045 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate

Exosome complex component RRP42 (EXOSC7), Human, ELISA Kit - CSB-EL007895HU from ARP American Research Products Category ELISA Kit Prices $615.00, $815.00 Sizes 48 t, 96 t

Securin (PTTG1), Human, ELISA Kit - CSB-EL019074HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

pituitary tumor-transforming 1, ELISA Kit - MBS947752 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 7.8 pg/ml. Range 31.2 pg/ml -2000 pg/ml.

PTTG1 Colorimetric Cell-Based ELISA - CB5827 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

Human Securin(PTTG1) ELISA kit - CSB-EL019074HU from Cusabio Category ELISA Kit Sensitivity 7.8 pg/ml Range 31.2 pg/ml-2000 pg/ml

PTTG1 ELISA Kit - DEIA-XYA1520 from Creative Diagnostics Category ELISA Kit

PTTG ELISA Kit - DEIA-XYA1519 from Creative Diagnostics Category ELISA Kit

Human Securin (PTTG1) ELISA Kit - EKC35481 from Biomatik Category ELISA Kit Prices $705.00, $2,820.00, $5,288.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 7.8 pg/ml Range 31.2 pg/ml-2000 pg/ml

Human PTTG1 ELISA Kit - E029449 from Biobool Category ELISA Kit Sensitivity 7.8 pg/ml.

anti-Securin antibody [DCS-280] - ARG62590 from Arigo Biolaboratories Category ELISA Kit

PTTG1 ELISA Kit (Human) (OKCA01506) - OKCA01506 from Aviva Systems Biology Category ELISA Kit Prices $600.00 Sizes 96 wells Sensitivity 7.8 pg/mL Range 31.2 - 2,000 pg/mL

Securin (PTTG1), ELISA Kit - MBS9345973 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Securin (PTTG1), ELISA Kit - MBS9370038 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Securin (PTTG1), ELISA Kit - MBS9370047 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Securin (PTTG1), ELISA Kit - MBS9347523 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Securin (PTTG1), ELISA Kit - MBS9349647 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Securin (PTTG1), ELISA Kit - MBS9361000 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Securin (PTTG1), ELISA Kit - MBS9346566 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Securin (PTTG1), ELISA Kit - MBS9347193 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Securin (PTTG1), ELISA Kit - MBS9351237 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Securin (PTTG1), ELISA Kit - MBS9367074 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Securin (PTTG1), ELISA Kit - MBS9344180 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Securin (PTTG1), ELISA Kit - MBS9361934 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Securin (PTTG1), ELISA Kit - MBS9350129 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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