| Gene Symbol | RPN1 |
|---|---|
| Entrez Gene | 6184 |
| Alt Symbol | OST1, RBPH1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | ribophorin I |
| Other Description | RPN-I|dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kDa subunit|dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1|dolichyl-diphosphooligosaccharide-protein glycosyltransferase 67 kDa subunit|oligosaccharyltransferase 1 homolog|oligosaccharyltransferase complex subunit (non-catalytic)|ribophorin-1 |
| Swissprots | P04843 Q68DT1 B2R5Z0 D3DNB6 |
| Accessions | CAH05344 CAH05363 EAW79306 EAW79307 EAW79308 EAW79309 P04843 AK223595 BAD97315 AK296905 BAG59461 AK297513 BAH12600 AK297941 BAG60257 AK312369 BAG35287 BC007995 AAH07995 BC010839 AAH10839 BF930946 BG720812 CR456742 CAG33023 CR749284 CAH18139 JF432331 ADZ15548 Y00281 CAA68392 NM_002950 NP_002941 |
| Function | Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. |
| Subcellular Location | Endoplasmic reticulum membrane; Single-pass type I membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. |
| Tissue Specificity | Expressed in all tissues tested. {ECO:0000269|PubMed:12887896}. |
| Top Pathways | N-Glycan biosynthesis, Protein processing in endoplasmic reticulum |