Gene Symbol | METTL11B |
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Entrez Gene | 149281 |
Alt Symbol | C1orf184, HOMT1B, NTM1B |
Species | Human |
Gene Type | protein-coding |
Description | methyltransferase like 11B |
Other Description | X-Pro-Lys N-terminal protein methyltransferase 1B|alpha N-terminal protein methyltransferase 1B|methyltransferase-like protein 11B |
Swissprots | Q5VVY1 B2RXI0 |
Accessions | Q5VVY1 BC157860 AAI57861 BC171858 AAI71858 XM_011509232 XP_011507534 XM_011509233 XP_011507535 XM_011509234 XP_011507536 NM_001136107 NP_001129579 |
Function | Alpha-N-methyltransferase that methylates the N-terminus of target proteins containing the N-terminal motif [Ala/Pro/Ser]- Pro-Lys when the initiator Met is cleaved. Specifically catalyzes monomethylation of exposed alpha-amino group of Ala or Ser residue in the [Ala/Ser]-Pro-Lys motif and Pro in the Pro-Pro-Lys motif. May activate NTMT1 by priming its substrates for trimethylation. {ECO:0000269|PubMed:24090352}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:24090352}. |
METTL11B CRISPR/Cas9 KO Plasmid (h) - sc-414653 from Santa Cruz Biotechnology
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METTL11B HDR Plasmid (h) - sc-414653-HDR from Santa Cruz Biotechnology
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METTL11B Double Nickase Plasmid (h) - sc-414653-NIC from Santa Cruz Biotechnology
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METTL11B Double Nickase Plasmid (h2) - sc-414653-NIC-2 from Santa Cruz Biotechnology
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METTL11B CRISPR Activation Plasmid (h) - sc-414653-ACT from Santa Cruz Biotechnology
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METTL11B CRISPR Activation Plasmid (h2) - sc-414653-ACT-2 from Santa Cruz Biotechnology
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METTL11B Lentiviral Activation Particles (h) - sc-414653-LAC from Santa Cruz Biotechnology
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METTL11B Lentiviral Activation Particles (h2) - sc-414653-LAC-2 from Santa Cruz Biotechnology
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METTL11B siRNA (h) - sc-88099 from Santa Cruz Biotechnology
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METTL11B shRNA Plasmid (h) - sc-88099-SH from Santa Cruz Biotechnology
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METTL11B shRNA (h) Lentiviral Particles - sc-88099-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU126141 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN13227 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND13227 from Sigma-Aldrich
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METTL11B siRNA (Human) - CRJ5611 from Cohesion Biosciences
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shRNA set against Human METTL11B (NM_001136107.1) - SHH340659 from Creative biogene
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METTL11B shRNA Plasmid (Human) - CHJ5611 from Cohesion Biosciences
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METTL11B miRNA 3'UTR clone - MiUTR4H-TG11726 from Creative biogene
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