Gene Symbol | Polr1e |
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Entrez Gene | 64424 |
Alt Symbol | 53kDa, AU042259, D030019D19Rik, Paf53, Praf1 |
Species | Mouse |
Gene Type | protein-coding |
Description | polymerase (RNA) I polypeptide E |
Other Description | DNA-directed RNA polymerase I subunit E|DNA-directed RNA polymerase I subunit RPA49|RNA polymerase I associated factor (Paf53)|RNA polymerase I subunit A49|RNA polymerase I-associated factor 53|polymerase (RNA) I associated factor 1 |
Swissprots | B1AXQ6 Q8BQG9 Q62034 B1AXQ7 Q8K202 |
Accessions | EDL02410 EDL02411 Q8K202 AK050780 BAC34409 AK083948 AK132556 BAE21232 BC034783 AAH34783 BY328290 D14336 BAA03266 NM_001285800 NP_001272729 NM_022811 NP_073722 |
Function | DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Appears to be involved in the formation of the initiation complex at the promoter by mediating the interaction between Pol I and UBTF/UBF. {ECO:0000269|PubMed:8641287, ECO:0000269|PubMed:9254723}. |
Subcellular Location | Nucleus, nucleolus {ECO:0000269|PubMed:8641287, ECO:0000269|PubMed:9254723}. |
Top Pathways | Purine metabolism, RNA polymerase, Pyrimidine metabolism |
POLR1E CRISPR/Cas9 KO Plasmid (m) - sc-425707 from Santa Cruz Biotechnology
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POLR1E HDR Plasmid (m) - sc-425707-HDR from Santa Cruz Biotechnology
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POLR1E Double Nickase Plasmid (m) - sc-425707-NIC from Santa Cruz Biotechnology
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POLR1E Double Nickase Plasmid (m2) - sc-425707-NIC-2 from Santa Cruz Biotechnology
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POLR1E CRISPR Activation Plasmid (m) - sc-425707-ACT from Santa Cruz Biotechnology
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POLR1E CRISPR Activation Plasmid (m2) - sc-425707-ACT-2 from Santa Cruz Biotechnology
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POLR1E Lentiviral Activation Particles (m) - sc-425707-LAC from Santa Cruz Biotechnology
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POLR1E Lentiviral Activation Particles (m2) - sc-425707-LAC-2 from Santa Cruz Biotechnology
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POLR1E siRNA (m) - sc-152370 from Santa Cruz Biotechnology
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POLR1E shRNA Plasmid (m) - sc-152370-SH from Santa Cruz Biotechnology
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POLR1E shRNA (m) Lentiviral Particles - sc-152370-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU080681 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN39033 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND39033 from Sigma-Aldrich
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POLR1E siRNA (Mouse) - CRM6312 from Cohesion Biosciences
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shRNA set against Mouse POLR1E (NM_022811.2) - SHH379368 from Creative biogene
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shRNA set against Mouse Polr1e(NM_022811.2) - SHR127208 from Creative biogene
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Mouse POLR1E siRNA - orb285788 from Biorbyt
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POLR1E shRNA Plasmid (Mouse) - CHM6312 from Cohesion Biosciences
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POLR1E miRNA 3'UTR clone - MiUTR1M-09398 from Creative biogene
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