SYNE2

Gene Symbol	SYNE2
Entrez Gene	23224
Alt Symbol	EDMD5, NUA, NUANCE, Nesp2, Nesprin-2, SYNE-2, TROPH
Species	Human
Gene Type	protein-coding
Description	spectrin repeat containing, nuclear envelope 2
Other Description	nesprin 2|nesprin-2|nuclear envelope spectrin repeat protein 2|nucleus and actin connecting element protein|polytrophin|synaptic nuclear envelope protein 2|synaptic nuclei expressed gene 2
Swissprots	Q8WXH1 Q8NF49 Q9Y2L4 Q8TER7 Q9UFQ4 B4DPR6 Q8WWW3 I6XXQ5 Q540G1 Q86YP9 Q8WWW5 Q8N1S3 Q8WWW4 B4DND7 Q9Y4R1 Q8WXH0
Accessions	EAW80838 EAW80839 EAW80840 EAW80841 EAW80842 EAW80843 EAW80844 Q8WXH0 AB023228 BAA76855 AF357236 AAQ15171 AF435010 AAL33547 AF435011 AAL33548 AF495911 AAN60443 AI685725 AK001876 AK074055 BAB84881 AK090430 BAC03411 AK095087 AK095241 BAC04506 AK125715 AK127612 AK128631 AK297874 BAG60199 AK298465 BAG60678 AL080133 CAB45729 AL117404 CAB55905 AY061757 AAL33800 AY061758 AAL33801 AY061759 AAL33802 AY184204 AAO27772 AY184205 AAO27773 AY927627 BC036941 BC042134 AAH42134 BC071873 AAH71873 BC154417 BX537642 BX538095 CAD98013 BX640974 CAE45988 BX648234 CR749324 CAH18179 DA825926 DB271849 JQ754367 AFN44385 XM_005267454 XP_005267511 XM_005267456 XP_005267513 XM_005267457 XP_005267514 XM_005267458 XP_005267515 XM_005267459 XP_005267516 XM_006720084 XP_006720147 XM_011536574 XP_011534876 XM_011536575 XP_011534877 XM_011536576 XP_011534878 XM_011536577 XP_011534879 XM_011536578 XP_011534880 XM_011536579 XP_011534881 XM_011536580 XP_011534882 XM_011536581 XP_011534883 XM_011536582 XP_011534884 XM_011536583 XP_011534885 XM_011536584 XP_011534886 NM_015180 NP_055995 NM_182910 NP_878914 NM_182913 NP_878917 NM_182914 NP_878918 NM_182912
Function	Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. Component of SUN-protein- containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Involved in the maintenance of nuclear organization and structural integrity. Connects nuclei to the cytoskeleton by interacting with the nuclear envelope and with F-actin in the cytoplasm. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. Required for centrosome migration to the apical cell surface during early ciliogenesis. {ECO:0000269|PubMed:12118075, ECO:0000269|PubMed:18396275, ECO:0000269|PubMed:19596800, ECO:0000269|PubMed:20724637
Subcellular Location	Nucleus outer membrane {ECO:0000305}; Single-pass type IV membrane protein {ECO:0000305}; Cytoplasmic side {ECO:0000305}. Sarcoplasmic reticulum membrane {ECO:0000305|PubMed:15671068}; Single-pass type IV membrane protein {ECO:0000305}. Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Cytoplasm, cytoskeleton. Mitochondrion. Nucleus, nucleoplasm. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000305|PubMed:15671068}. Note=Different isoform patterns are found in the different compartments of the cell. The isoforms having the C-terminal transmembrane span can be found in several organellar membranes like the nuclear envelope, the sarcoplasmic reticulum of myoblasts, or the lamellipodia and focal adhesions at the cell membrane. The largest part of the outer nuclear membrane-associated protein is cytoplasmic, while its C-terminal part is associated with the nuclear envelope, most probably the outer nuclear membrane. Remains associated with the nuclear envelope during
Tissue Specificity	Widely expressed, with higher level in kidney, adult and fetal liver, stomach and placenta. Weakly expressed in skeletal muscle and brain. Isoform 5 is highly expressed in pancreas, skeletal muscle and heart. {ECO:0000269|PubMed:15671068}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Syne-2 (C-1) - sc-365097 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Syne-2 (D-1) - sc-365431 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

Syne-2 (E-18) - sc-51220 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Syne-2 (H-109) - sc-99066 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

Anti-Nesprin 2 antibody - ab57397 from Abcam Prices $385.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-Nesprin 2 antibody - ab103020 from Abcam Prices $376.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Nesprin 2 Antibody - NBP1-84190 from Novus Biologicals Prices $129.00, $419.00 Sizes 25 µl, 100 µl Host Rabbit Clonality Polyclonal

Nesprin 2 Antibody - NBP2-38620 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Nesprin 2 Antibody (5E5) - H00023224-M01 from Novus Biologicals Prices $359.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 5E5

Nesprin 2 Antibody - H00023224-A01 from Novus Biologicals Prices $269.00 Sizes 50 µl Host Mouse Clonality Polyclonal

Anti-SYNE2 antibody produced in rabbit - HPA003435 from Sigma-Aldrich Prices $429.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Monoclonal Anti-SYNE2 antibody produced in mouse - WH0023224M1 from Sigma-Aldrich Prices $347.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 5E5

Nesprin-2 antibody - 25265-1-AP from Acris Antibodies Prices $270.00 Sizes 150 µl Host Rabbit Clonality Polyclonal

Nesprin-2 antibody - H00023224-A01 from Acris Antibodies Prices $300.00 Sizes 50 µl Host Mouse Clonality Polyclonal

Nesprin-2 antibody - H00023224-M01 from Acris Antibodies Prices $360.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 5E5

Nesprin-2 antibody - IQ562 from Acris Antibodies Prices $380.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone K20-478-5

SYNE2 antibody - 25265-1-AP from Proteintech Group Prices $279.00 Sizes con: 51 μg/150μl Host Rabbit Clonality Polyclonal

SYNE2, Monoclonal Antibody - MBS6008947 from MyBioSource Prices $580.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 5E5

Anti-SYNE2 (aa 6702-6799) polyclonal antibody - DPAB-DC1065 from Creative Diagnostics Host Mouse Clonality Polyclonal

Anti-SYNE2 (aa 6350-6450) polyclonal antibody - DPABH-12474 from Creative Diagnostics Host Rabbit Clonality Polyclonal

Monoclonal Antibody to Nesprin 2 (Nesp2) - MAF952Hu21 from Uscn Life Science Inc. Host Mouse Clonality Monoclonal

Polyclonal Antibody to Nesprin 2 (Nesp2) - PAF952Hu01 from Uscn Life Science Inc. Host Rabbit Clonality Polyclonal

Nesprin 2 Monoclonal Antibody (K20-478-5) - MA5-18075 from Thermo Fisher Scientific Prices $425.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone K20-478-5

Anti-spectrin repeat containing, nuclear envelope 2 - 08A023224 from MP Biomedicals Prices $456.30 Sizes 100 μg Host Mouse Clonality Monoclonal Clone 5E5

Anti-Nesprin-2 Antibody, clone K20-478 - MABC86 from EMD Millipore Prices $289.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone K20-478

Search more