| Gene Symbol |
Cyp7a1
|
| Entrez Gene |
13122
|
| Alt Symbol |
-
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
cytochrome P450, family 7, subfamily a, polypeptide 1
|
| Other Description |
CYPVII|cholesterol 7 alpha hydroxylase|cholesterol 7-alpha-hydroxylase|cholesterol 7-alpha-monooxygenase|cytochrome P450 7A1|cytochrome P450, 7a1
|
| Swissprots |
Q8BFR7 Q64505
|
| Accessions |
AAA68867 EDL05690 Q64505 AK050020 BAC34033 AK050210 BAC34123 AK050220 BAC34131 AK050260 BAC34150 BC130261 AAI30262 XM_006537603 XP_006537666 XM_006537604 XP_006537667 NM_007824 NP_031850
|
| Function |
Catalyzes a rate-limiting step in cholesterol catabolism and bile acid biosynthesis by introducing a hydrophilic moiety at position 7 of cholesterol. Important for cholesterol homeostasis. {ECO:0000269|PubMed:14522988}.
|
| Subcellular Location |
Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
|
| Top Pathways |
Primary bile acid biosynthesis, Steroid hormone biosynthesis, PPAR signaling pathway, Bile secretion
|