LTA

Gene Symbol	LTA
Entrez Gene	4049
Alt Symbol	LT, TNFB, TNFSF1
Species	Human
Gene Type	protein-coding
Description	lymphotoxin alpha
Other Description	LT-alpha|TNF superfamily, member 1|TNF-beta|lymphotoxin-alpha|tumor necrosis factor beta|tumor necrosis factor ligand superfamily member 1
Swissprots	Q8N4C3 Q9UKS8 P01374
Accessions	AAA61199 AAB59455 AAD18092 AAL49956 AAO21135 AAP51421 AAP51422 AAP51423 AAP51424 AAP51425 AAP51426 AAP51427 AAP51428 AAP51429 AAP51430 AAP51431 AAP51432 AAP51433 AAP51434 AAP51435 AAP51436 AAP51437 AAP51438 AAP51439 AAP51440 AAP51441 AAP51442 AAP51443 AAP51444 ACA64643 ACA64644 ACA64645 ACA64646 AHH34316 AHH34317 AHH34318 AHH34319 AHH34320 AHH34321 AHH34322 AHH34323 AHH34324 AHI45173 AHI45174 AHI45175 AHI45176 BAB63397 BAC54943 BAE78638 BAF31278 CAA26670 CAA75071 CAA78746 CAI95949 EAX03422 EAX03423 P01374 A06316 CAA00536 BC034729 AAH34729 BG685356 BP338937 BX108399 CR542253 CAG47049 CR542273 CAG47069 D00102 BAA00064 D12614 BAA02139 DQ123821 AAZ32914 DQ123822 AAZ32915 DQ123823 AAZ32916 DQ123824 AAZ32917 DQ123825 AAZ32918 DQ123826 AAZ32919 DQ123827 AAZ32920 DQ891119 ABM82045 DQ894298 ABM85224 X01393 CAA25649 XM_011514614 XP_011512916 XM_011514615 XP_011512917 XM_011514616 XP_011512918 XM_011514617 XP_011512919 XM_011514618 XP_011512920 XM_011547250 XP_011545552 XM_011547653 XP_011545955 XM_011547654 XP_011545956 XM_011547883 XP_011546185 XM_011547884 XP_011546186 XM_011547885 XP_011546187 XM_011547886 XP_011546188 XM_011547887 XP_011546189 XM_011548050 XP_011546352 XM_011548051 XP_011546353 XM_011548242 XP_011546544 XM_011548243 XP_011546545 XM_011548436 XP_011546738 XM_011548437 XP_011546739 XM_011548438 XP_011546740 XM_011548439 XP_011546741 XM_011548440 XP_011546742 NM_000595 NP_000586 NM_001159740 NP_001153212
Function	Cytokine that in its homotrimeric form binds to TNFRSF1A/TNFR1, TNFRSF1B/TNFBR and TNFRSF14/HVEM. In its heterotrimeric form with LTB binds to TNFRSF3/LTBR. Lymphotoxin is produced by lymphocytes and cytotoxic for a wide range of tumor cells in vitro and in vivo.
Subcellular Location	Secreted. Membrane. Note=The homotrimer is secreted. The heterotrimer is membrane-associated.
Top Pathways	Cytokine-cytokine receptor interaction, Type I diabetes mellitus, HTLV-I infection, Herpes simplex infection, TNF signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human TNF beta full length protein - ab168721 from Abcam Category Protein Prices $465.00 Sizes 50 µg Source E. coli Species Human

Active human TNF beta full length protein - ab194040 from Abcam Category Protein Prices $176.00 Sizes 4 µg Source Mammalian Species Human

Active human TNF beta full length protein - ab182708 from Abcam Category Protein Prices $247.00 Sizes 10 µg Source HEK 293 cells Species Human

Active human TNF beta full length protein - ab639 from Abcam Category Protein Prices $110.00, $257.00 Sizes 5 µg, 20 µg Source E. coli Species Human

Active human TNF beta full length protein - ab192107 from Abcam Category Protein Prices $192.00 Sizes 20 µg Source E. coli Species Human

Active human TNF beta protein fragment - ab168044 from Abcam Category Protein Prices $410.00 Sizes 10 µg Source E. coli Species Human

Human TNF beta full length protein - ab61267 from Abcam Category Protein Source E. coli Species Human

Simian Virus 40 (SV40) SV40 Large T Antigen full length protein - ab82118 from Abcam Category Protein Source Baculovirus Species Simian virus 40

LTA / TNF Beta Antibody Blocking Peptide - LS-E9608 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Lymphotoxin-alpha/TNF-beta Partial Recombinant Protein - H00004049-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Lymphotoxin-alpha/TNF-beta Recombinant Protein - H00004049-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Lymphotoxin-alpha/TNF-beta Recombinant Protein - H00004049-P02 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Lymphotoxin-alpha/TNF-beta Protein - NBP1-41147 from Novus Biologicals Category Protein Prices $369.00 Sizes 50 µg Species Human

Lymphotoxin-alpha/TNF-beta Recombinant Protein - P3669 from Novus Biologicals Category Protein Prices $369.00 Sizes 20 µg Species Human

Lymphotoxin-alpha/TNF-beta Recombinant Protein - P3506 from Novus Biologicals Category Protein Prices $669.00 Sizes 50 µg Species Human

Lymphotoxin-alpha/TNF-beta Protein - NBP1-91283 from Novus Biologicals Category Protein Prices $529.00 Sizes 10 µg Species Human

Lymphotoxin-alpha/TNF-beta Protein - NBP1-99354 from Novus Biologicals Category Protein Prices $309.00 Sizes 20 µg Species Human

Lymphotoxin-alpha/TNF-beta Protein - NBP2-26528 from Novus Biologicals Category Protein Prices $539.00 Sizes 20 µg Species Human

LTA-Antibody-Center-Blocking-Peptide - BP8509c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

TNF beta protein - GTX20639 from GeneTex Category Protein Prices $269.00 Sizes 20 μg Species Human

TNF beta Recombinant Protein (Active) - GTX48402-PRO from GeneTex Category Protein Prices $299.00 Sizes 20 μg Source E. coli Species Human

TNF beta recombinant protein - GTX65166 from GeneTex Category Protein Prices $249.00 Sizes 20 μg Source E. coli Species Human

Recombinant Human Lymphotoxin alpha1/beta2 - 678-LY-010 from R&D Systems Category Protein Source Spodoptera frugiperda, Sf 21 (baculovirus)-derived, Leu35-Leu205 (LT alpha ) & Leu54-Gly244 (LT beta ), both with an N-terminal Met & Thr41-Leu205 (LT alpha )

Recombinant Human Lymphotoxin alpha1/beta2, CF - 678-LY-010/CF from R&D Systems Category Protein Source Spodoptera frugiperda, Sf 21 (baculovirus)-derived, Leu35-Leu205 (LT alpha ) & Leu54-Gly244 (LT beta ), both with an N-terminal Met & Thr41-Leu205 (LT alpha )

Recombinant Human Lymphotoxin alpha2/beta1 - 679-TX-010 from R&D Systems Category Protein Source Spodoptera frugiperda, Sf 21 (baculovirus)-derived, Leu35-Leu205 (LT alpha ) & Leu54-Gly244 (LT beta ), both with an N-terminal Met & Thr41 ‑ Leu205 (LT alpha )

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