Gene Symbol | VPS53 |
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Entrez Gene | 55275 |
Alt Symbol | HCCS1, PCH2E, hVps53L, pp13624 |
Species | Human |
Gene Type | protein-coding |
Description | vacuolar protein sorting 53 homolog (S. cerevisiae) |
Other Description | vacuolar protein sorting-associated protein 53 homolog |
Swissprots | Q8WYW3 Q9NV25 B3FH42 A8K2S8 Q9BY02 Q9BRR2 Q5VIR6 |
Accessions | EAW90658 EAW90659 EAW90660 EAW90661 EAW90662 Q5VIR6 AF085927 AF246287 AAK27973 AF318335 AAL55842 AK001841 BAA91935 AK056323 AK057942 AK091388 AK092532 BAG52568 AK123107 AK290343 BAF83032 AK299543 BAH13062 AL701573 AY444797 AAS20944 BC006116 AAH06116 BC029560 AAH29560 BC039432 BC040223 CB851054 EU021218 ABW03005 EU434648 ACA21423 EU434649 ACA21424 EU434650 ACA21425 XM_011523953 XP_011522255 XR_934061 XR_934062 NM_001128159 NP_001121631 NM_018289 NP_060759 |
Function | May be involved in retrograde transport of early and late endosomes to the late Golgi. The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. {ECO:0000269|PubMed:15878329, ECO:0000269|PubMed:18367545}. |
Subcellular Location | Golgi apparatus, trans-Golgi network membrane; Peripheral membrane protein. Endosome membrane; Peripheral membrane protein. |
VPS53 CRISPR/Cas9 KO Plasmid (h) - sc-410501 from Santa Cruz Biotechnology
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VPS53 HDR Plasmid (h) - sc-410501-HDR from Santa Cruz Biotechnology
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VPS53 Double Nickase Plasmid (h) - sc-410501-NIC from Santa Cruz Biotechnology
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VPS53 Double Nickase Plasmid (h2) - sc-410501-NIC-2 from Santa Cruz Biotechnology
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VPS53 CRISPR Activation Plasmid (h) - sc-410501-ACT from Santa Cruz Biotechnology
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VPS53 CRISPR Activation Plasmid (h2) - sc-410501-ACT-2 from Santa Cruz Biotechnology
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VPS53 Lentiviral Activation Particles (h) - sc-410501-LAC from Santa Cruz Biotechnology
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VPS53 Lentiviral Activation Particles (h2) - sc-410501-LAC-2 from Santa Cruz Biotechnology
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VPS53 siRNA (h) - sc-93834 from Santa Cruz Biotechnology
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VPS53 shRNA Plasmid (h) - sc-93834-SH from Santa Cruz Biotechnology
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VPS53 shRNA (h) Lentiviral Particles - sc-93834-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU157401 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN22731 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22731 from Sigma-Aldrich
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VPS53 siRNA (Human) - CRJ0615 from Cohesion Biosciences
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VPS53 - MBS8214017 from MyBioSource
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shRNA set against Human VPS53 (NM_018289.3) - SHH445096 from Creative biogene
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Human VPS53 siRNA - orb271116 from Biorbyt
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VPS53 shRNA Plasmid (Human) - CHJ0615 from Cohesion Biosciences
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VPS53 miRNA 3'UTR clone - MiUTR3H-16535 from Creative biogene
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