Gene Symbol | ZNF207 |
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Entrez Gene | 7756 |
Alt Symbol | BuGZ |
Species | Human |
Gene Type | protein-coding |
Description | zinc finger protein 207 |
Other Description | BUB3-interacting and GLEBS motif-containing protein ZNF207 |
Swissprots | Q9BUQ7 E1P660 Q53XS9 Q96HW5 O43670 E1P662 E1P661 A8K6Y6 |
Accessions | EAW80231 EAW80232 EAW80233 EAW80234 EAW80235 EAW80236 EAW80237 O43670 AB209215 BAD92452 AF046001 AAC78561 AI308956 AK026215 AK226172 AK291801 BAF84490 AK298950 BAG61049 AK309979 AL834501 CAD39159 BC000962 BC002372 AAH02372 BC008023 AAH08023 BT007365 AAP36029 CN276833 JF432111 ADZ15328 XM_005258029 XP_005258086 XM_011525185 XP_011523487 XR_934542 XR_934543 XR_934544 NM_001032293 NP_001027464 NM_001098507 NP_001091977 NM_003457 NP_003448 |
Function | Kinetochore-binding protein involved in spindle-assembly checkpoint signaling by regulating mitotic chromosome alignment and mediating the stability and kinetochore loading of BUB3. Mechanisms by which BUB3 is protected are unclear: according to a first report, ZNF207/BuGZ may act by blocking ubiquitination and proteasomal degradation of BUB3 (PubMed:24462186). According to another report, the stabilization is independent of the proteasome (PubMed:24462187). {ECO:0000269|PubMed:24462186, ECO:0000269|PubMed:24462187}. |
Subcellular Location | Nucleus. Chromosome, centromere, kinetochore. Note=Localizes primarily to the nucleus in interphase, concentrates at kinetochores prior to nuclear envelope breakdown and during early prometaphase, and disappears from kinetochores upon microtubule-binding. |
Tissue Specificity | Ubiquitous. |
ZNF207 (A-7) - sc-271277 from Santa Cruz Biotechnology
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ZNF207 (C-6) - sc-271943 from Santa Cruz Biotechnology
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ZNF207 (D-12) - sc-109178 from Santa Cruz Biotechnology
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ZNF207 (E-2) - sc-271942 from Santa Cruz Biotechnology
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ZNF207 (H-300) - sc-98648 from Santa Cruz Biotechnology
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ZNF207 (N-14) - sc-109179 from Santa Cruz Biotechnology
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ZNF207 (P-14) - sc-109180 from Santa Cruz Biotechnology
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Anti-ZNF207 antibody - ab88262 from Abcam
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Anti-ZNF207 antibody - ab26258 from Abcam
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Anti-ZNF207 antibody - ab123322 from Abcam
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Anti-ZNF207 antibody - ab58190 from Abcam
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Anti-ZNF207 antibody - ab58196 from Abcam
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Anti-ZNF207 Antibody (aa1-111, clone 10B2560, Azide-free) - LS-C183726 from LifeSpan Bioscience
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Anti-ZNF207 Antibody (aa88-116, APC) - LS-C274236 from LifeSpan Bioscience
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Anti-ZNF207 Antibody (aa88-116, AP) - LS-C274235 from LifeSpan Bioscience
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Anti-ZNF207 Antibody (aa88-116, Biotin) - LS-C274237 from LifeSpan Bioscience
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Anti-ZNF207 Antibody (aa88-116, Azide-free, HRP) - LS-C274238 from LifeSpan Bioscience
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Anti-ZNF207 Antibody (aa88-116, FITC) - LS-C274239 from LifeSpan Bioscience
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Anti-ZNF207 Antibody (aa88-116, PE) - LS-C274240 from LifeSpan Bioscience
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Anti-ZNF207 Antibody (aa87-116) - LS-C326547 from LifeSpan Bioscience
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Anti-ZNF207 Antibody (aa223-271) - LS-C31142 from LifeSpan Bioscience
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Anti-ZNF207 Antibody (aa360-409) - LS-C101451 from LifeSpan Bioscience
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Anti-ZNF207 Antibody (aa88-116) - LS-C160836 from LifeSpan Bioscience
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Anti-ZNF207 Antibody (clone 6D7) - LS-C133524 from LifeSpan Bioscience
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ZNF207 Antibody - NBP1-89550 from Novus Biologicals
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