| Gene Symbol |
PON2
|
| Entrez Gene |
5445
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
paraoxonase 2
|
| Other Description |
A-esterase 2|PON 2|aromatic esterase 2|arylesterase 2|paraoxonase nirs|serum aryldialkylphosphatase 2|serum paraoxonase/arylesterase 2
|
| Swissprots |
A4D1H7 O75856 Q86YL0 B4DJD5 O15114 Q15165 B2RCP9 Q5FBX7 O15115
|
| Accessions |
AAC27946 AAC62431 AAO18083 EAL24131 EAW76763 EAW76764 EAW76765 EAW76766 EAW76767 Q15165 AB102891 BAD89420 AF001601 AAC27944 AF001602 AAC27945 AK054688 AK291103 BAF83792 AK296029 BAG58797 AK296636 BAG59238 AK301313 BAG62864 AK308065 AK315209 BAG37646 BC009728 AAH09728 BC040010 AAH40010 BC046160 AAH46160 BC073739 BC093006 CB961097 L48513 AAC41995 XM_005250453 XP_005250510 XM_005250454 XP_005250511 XM_011516333 XP_011514635 NM_000305 NP_000296 NM_001018161 NP_001018171
|
| Function |
Capable of hydrolyzing lactones and a number of aromatic carboxylic acid esters. Has antioxidant activity. Is not associated with high density lipoprotein. Prevents LDL lipid peroxidation, reverses the oxidation of mildly oxidized LDL, and inhibits the ability of MM-LDL to induce monocyte chemotaxis. {ECO:0000269|PubMed:11579088, ECO:0000269|PubMed:15772423}.
|
| Subcellular Location |
Membrane {ECO:0000269|PubMed:11579088}; Peripheral membrane protein {ECO:0000269|PubMed:11579088}.
|
| Tissue Specificity |
Widely expressed with highest expression in liver, lung, placenta, testis and heart. {ECO:0000269|PubMed:11579088}.
|
![Western Blot: PON2 Overexpression Lysate (Adult Normal) [NBL1-14605] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for PON2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/920_PON2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-14605-img0002.jpg)