| Gene Symbol |
TRAM2
|
| Entrez Gene |
9697
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
translocation associated membrane protein 2
|
| Other Description |
TRAM-like protein|translocating chain-associated membrane protein 2
|
| Swissprots |
Q15035 A8K6T6
|
| Accessions |
EAX04373 EAX04374 EAX04375 Q15035 AA044636 AB621814 BAK64150 AK291751 BAF84440 AK311560 AU140711 AY927571 AY927606 BC016804 BC028121 AAH28121 BG323472 BG821383 CF264873 CK000467 D31077 D31762 BAA06540 DQ891068 ABM81994 DQ894250 ABM85176 H59725 XM_011515005 XP_011513307 NM_012288 NP_036420
|
| Function |
Necessary for collagen type I synthesis. May couple the activity of the ER Ca(2+) pump SERCA2B with the activity of the translocon. This coupling may increase the local Ca(2+) concentration at the site of collagen synthesis, and a high Ca(2+) concentration may be necessary for the function of molecular chaperones involved in collagen folding. {ECO:0000269|PubMed:14749390}.
|
| Subcellular Location |
Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
|
![Western Blot: TRAM2 Overexpression Lysate (Adult Normal) [NBL1-17254] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for TRAM2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/5376_TRAM2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-17254-img0002.jpg)