Gene Symbol | TRAM2 |
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Entrez Gene | 9697 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | translocation associated membrane protein 2 |
Other Description | TRAM-like protein|translocating chain-associated membrane protein 2 |
Swissprots | Q15035 A8K6T6 |
Accessions | EAX04373 EAX04374 EAX04375 Q15035 AA044636 AB621814 BAK64150 AK291751 BAF84440 AK311560 AU140711 AY927571 AY927606 BC016804 BC028121 AAH28121 BG323472 BG821383 CF264873 CK000467 D31077 D31762 BAA06540 DQ891068 ABM81994 DQ894250 ABM85176 H59725 XM_011515005 XP_011513307 NM_012288 NP_036420 |
Function | Necessary for collagen type I synthesis. May couple the activity of the ER Ca(2+) pump SERCA2B with the activity of the translocon. This coupling may increase the local Ca(2+) concentration at the site of collagen synthesis, and a high Ca(2+) concentration may be necessary for the function of molecular chaperones involved in collagen folding. {ECO:0000269|PubMed:14749390}. |
Subcellular Location | Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. |
TRAM2 CRISPR/Cas9 KO Plasmid (h) - sc-409747 from Santa Cruz Biotechnology
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TRAM2 HDR Plasmid (h) - sc-409747-HDR from Santa Cruz Biotechnology
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TRAM2 Double Nickase Plasmid (h) - sc-409747-NIC from Santa Cruz Biotechnology
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TRAM2 Double Nickase Plasmid (h2) - sc-409747-NIC-2 from Santa Cruz Biotechnology
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TRAM2 CRISPR Activation Plasmid (h) - sc-409747-ACT from Santa Cruz Biotechnology
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TRAM2 CRISPR Activation Plasmid (h2) - sc-409747-ACT-2 from Santa Cruz Biotechnology
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TRAM2 Lentiviral Activation Particles (h) - sc-409747-LAC from Santa Cruz Biotechnology
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TRAM2 Lentiviral Activation Particles (h2) - sc-409747-LAC-2 from Santa Cruz Biotechnology
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TRAM2 siRNA (h) - sc-95376 from Santa Cruz Biotechnology
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TRAM2 shRNA Plasmid (h) - sc-95376-SH from Santa Cruz Biotechnology
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TRAM2 shRNA (h) Lentiviral Particles - sc-95376-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU027821 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN21918 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21918 from Sigma-Aldrich
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TRAM2 siRNA (Human) - CRH6468 from Cohesion Biosciences
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TRAM2 - MBS8231351 from MyBioSource
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shRNA set against Human TRAM2 (NM_012288.3) - SHH433868 from Creative biogene
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shRNA set against Human TRAM2(NM_012288.3) - SHL091650 from Creative biogene
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Human TRAM2 siRNA - orb266970 from Biorbyt
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TRAM2 shRNA Plasmid (Human) - CHH6468 from Cohesion Biosciences
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TRAM2 miRNA 3'UTR clone - MiUTR1H-10700 from Creative biogene
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