| Gene Symbol |
RGS19
|
| Entrez Gene |
10287
|
| Alt Symbol |
GAIP, RGSGAIP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
regulator of G-protein signaling 19
|
| Other Description |
G alpha interacting protein|G protein signalling regulator 19|G-alpha-interacting protein|guanine nucleotide binding protein alpha inhibiting activity polypeptide 3 interacting protein|regulator of G-protein signalling 19
|
| Swissprots |
Q53XN0 P49795 E1P5G9 A8K216 Q8TD60
|
| Accessions |
AAG42352 EAW75166 EAW75167 P49795 AF285096 AF285097 AF493939 AAM12653 AK290081 BAF82770 AK298240 BAG60506 AY585188 AAS94232 BC001318 AAH01318 BC054337 AAH54337 BC063010 AAH63010 BM554550 BT009804 AAP88806 CR457430 CAG33711 DQ891204 ABM82130 DQ894387 ABM85313 X91809 CAA62919 XM_005260182 XP_005260239 XM_005260183 XP_005260240 XM_011528484 XP_011526786 XM_011528485 XP_011526787 XM_011528486 XP_011526788 NM_005873 NP_005864 NM_001039467 NP_001034556
|
| Function |
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G-alpha subfamily 1 members, with the order G(i)a3 > G(i)a1 > G(o)a >> G(z)a/G(i)a2. Activity on G(z)-alpha is inhibited by phosphorylation and palmitoylation of the G-protein.
|
| Subcellular Location |
Membrane; Lipid-anchor.
|
| Tissue Specificity |
Highest expression in lung. Placenta, liver and heart also express high levels of GAIP.
|