| Gene Symbol | CACNA1H |
|---|---|
| Entrez Gene | 8912 |
| Alt Symbol | CACNA1HB, Cav3.2, ECA6, EIG6 |
| Species | Human |
| Gene Type | protein-coding |
| Description | calcium channel, voltage-dependent, T type, alpha 1H subunit |
| Other Description | calcium channel, voltage-dependent, T type, alpha 1Hb subunit|low-voltage-activated calcium channel alpha1 3.2 subunit|low-voltage-activated calcium channel alpha13.2 subunit|voltage dependent t-type calcium channel alpha-1H subunit|voltage-dependent T-type calcium channel subunit alpha-1H|voltage-gated calcium channel alpha subunit Cav3.2|voltage-gated calcium channel alpha subunit CavT.2|voltage-gated calcium channel subunit alpha Cav3.2 |
| Swissprots | Q96RZ9 Q96QI6 Q9NYY4 B5ME00 Q9NYY5 O95180 F8WFD1 O95802 Q8WWI6 |
| Accessions | AAF60160 AAF60161 AAF60162 AAF60163 AAK61268 CAC42094 EAW85683 EAW85684 O95180 AF051946 AAC67239 AF070604 AF073931 AAD17668 AJ420779 CAD12646 AK074965 BAG52041 BM554380 CA335096 CD243650 DQ363526 ABC88009 DQ363527 ABC88010 DQ363528 ABC88011 DQ363529 ABC88012 XM_005255652 XP_005255709 XM_006720963 XP_006721026 XM_006720964 XP_006721027 XM_006720965 XP_006721028 XM_006720967 XP_006721030 XM_006720968 XP_006721031 XM_006720969 XP_006721032 XM_011522724 XP_011521026 XM_011522725 XP_011521027 XM_011522726 XP_011521028 XM_011522727 XP_011521029 XR_932960 NM_001005407 NP_001005407 NM_021098 NP_066921 |
| Function | Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1H gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. |
| Subcellular Location | Membrane; Multi-pass membrane protein. |
| Tissue Specificity | Expressed in kidney, liver, heart, brain. Isoform 2 seems to be testis-specific. |
| Top Pathways | MAPK signaling pathway, Calcium signaling pathway, Circadian entrainment |
T-type Ca ++ CP α1H CRISPR/Cas9 KO Plasmid (h) - sc-401147 from Santa Cruz Biotechnology
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T-type Ca ++ CP α1H HDR Plasmid (h) - sc-401147-HDR from Santa Cruz Biotechnology
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T-type Ca ++ CP α1H Double Nickase Plasmid (h) - sc-401147-NIC from Santa Cruz Biotechnology
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T-type Ca ++ CP α1H Double Nickase Plasmid (h2) - sc-401147-NIC-2 from Santa Cruz Biotechnology
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T-type Ca ++ CP α1H CRISPR Activation Plasmid (h) - sc-401147-ACT from Santa Cruz Biotechnology
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T-type Ca ++ CP α1H CRISPR Activation Plasmid (h2) - sc-401147-ACT-2 from Santa Cruz Biotechnology
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T-type Ca ++ CP α1H Lentiviral Activation Particles (h) - sc-401147-LAC from Santa Cruz Biotechnology
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T-type Ca ++ CP α1H Lentiviral Activation Particles (h2) - sc-401147-LAC-2 from Santa Cruz Biotechnology
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T-type Ca ++ CP α1H siRNA (h) - sc-42706 from Santa Cruz Biotechnology
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T-type Ca ++ CP α1H shRNA Plasmid (h) - sc-42706-SH from Santa Cruz Biotechnology
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T-type Ca ++ CP α1H shRNA (h) Lentiviral Particles - sc-42706-V from Santa Cruz Biotechnology
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Cav3.2 RNAi - H00008912-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN2471 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2471 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR06657 from Sigma-Aldrich
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CACNA1H siRNA (Human) - CRH5894 from Cohesion Biosciences
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Cav3.2 RNAi - H00008912-R02 from Novus Biologicals
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CACNA1H - MBS8227438 from MyBioSource
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T-type Ca++ CP α1H CRISPR/Cas9 KO Plasmid (h2) - sc-401147-KO-2 from Santa Cruz Biotechnology
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T-type Ca++ CP α1H HDR Plasmid (h2) - sc-401147-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human CACNA1H (NM_021098.2) - SHH253333 from Creative biogene
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shRNA set against Human CACNA1H(NM_001005407.1) - SHG133369 from Creative biogene
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shRNA set against Human CACNA1H(NM_021098.2) - SHG133405 from Creative biogene
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Human CACNA1H siRNA - orb266396 from Biorbyt
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CACNA1H shRNA Plasmid (Human) - CHH5894 from Cohesion Biosciences
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