CACNA1H

Gene Symbol CACNA1H
Entrez Gene 8912
Alt Symbol CACNA1HB, Cav3.2, ECA6, EIG6
Species Human
Gene Type protein-coding
Description calcium channel, voltage-dependent, T type, alpha 1H subunit
Other Description calcium channel, voltage-dependent, T type, alpha 1Hb subunit|low-voltage-activated calcium channel alpha1 3.2 subunit|low-voltage-activated calcium channel alpha13.2 subunit|voltage dependent t-type calcium channel alpha-1H subunit|voltage-dependent T-type calcium channel subunit alpha-1H|voltage-gated calcium channel alpha subunit Cav3.2|voltage-gated calcium channel alpha subunit CavT.2|voltage-gated calcium channel subunit alpha Cav3.2
Swissprots Q96RZ9 Q96QI6 Q9NYY4 B5ME00 Q9NYY5 O95180 F8WFD1 O95802 Q8WWI6
Accessions AAF60160 AAF60161 AAF60162 AAF60163 AAK61268 CAC42094 EAW85683 EAW85684 O95180 AF051946 AAC67239 AF070604 AF073931 AAD17668 AJ420779 CAD12646 AK074965 BAG52041 BM554380 CA335096 CD243650 DQ363526 ABC88009 DQ363527 ABC88010 DQ363528 ABC88011 DQ363529 ABC88012 XM_005255652 XP_005255709 XM_006720963 XP_006721026 XM_006720964 XP_006721027 XM_006720965 XP_006721028 XM_006720967 XP_006721030 XM_006720968 XP_006721031 XM_006720969 XP_006721032 XM_011522724 XP_011521026 XM_011522725 XP_011521027 XM_011522726 XP_011521028 XM_011522727 XP_011521029 XR_932960 NM_001005407 NP_001005407 NM_021098 NP_066921
Function Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1H gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes.
Subcellular Location Membrane; Multi-pass membrane protein.
Tissue Specificity Expressed in kidney, liver, heart, brain. Isoform 2 seems to be testis-specific.
Top Pathways MAPK signaling pathway, Calcium signaling pathway, Circadian entrainment

T-type Ca ++ CP α1H (G-10) - sc-377510 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
T-type Ca<sup>++</sup> CP α1H (G-10): sc-377510. Western blot analysis of T-type Ca<sup>++</sup> CP α1H expression in human placenta (A) and extracellular matrix (B) tissue extracts.

T-type Ca ++ CP α1H (C-20) - sc-16263 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
T-type Ca<sup>++</sup> CP α1H (C-20): sc-16263. Immunoperoxidase staining of formalin fixed, paraffin-embedded human placenta tissue showing cytoplasmic staining of trophoblastic cells and cytoplasmic and nuclear staining of decidual cells.

T-type Ca ++ CP α1H (H-300) - sc-25691 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
T-type Ca<sup>++</sup> CP α1H (H-300): sc-25691. Western blot analysis of T-type Ca<sup>++</sup> CP α1H expression in human placenta tissue extract.

T-type Ca ++ CP α1H (H-110) - sc-28616 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
T-type Ca<sup>++</sup> CP α1H (H-110): sc-28616. Immunoperoxidase staining of formalin fixed, paraffin-embedded human heart muscle tissue showing cytoplasmic staining of myocytes.

T-type Ca ++ CP α1H (N-18) - sc-16261 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-CACNA1G + CACNA1H antibody - ab81099 from Abcam

Host Rabbit
Clonality Polyclonal
ab81099 staining CACNA1G + CACNA1H in rabbit heart tissue by Immunohistochemistry (Frozen sections).Tissue was fixed in paraformaldehyde, blocked with 6% BSA for 1 hour at 25°C and then incubated with ab81099 at a 1/50 dilution for 1 hour at 25°C. The secondary used was an Alexa-Fluor 488 conjugated goat anti-rabbit polyclonal used at a 1/500 dilution.Note clean membrane staining for atrial cells.See Abreview

Anti-CACNA1G + CACNA1H antibody - ab95092 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-CACNA1G + CACNA1H antibody (ab95092) at 1 µg/ml (in 5% skim milk / PBS buffer) + Human fetal spleen lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-CACNA1H antibody - ab128251 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-CACNA1H antibody - ab135974 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-CACNA1H antibody (ab135974) at 1/500 dilution + HeLa cell lysate at 30 µg

Anti-CACNA1H antibody [S55-10] - ab84815 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S55-10
ab84815 staining CACCNA1H in human hippocampal tissue by IHC-P (Bouin's fixed paraffin embedded).

Anti-CACNA1H / Cav3.2 Antibody (aa1019-1293) - LS-C122826 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-CACNA1H / Cav3.2 Antibody (clone S55-10) - LS-C152674 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S55-10

Anti-CACNA1H / Cav3.2 Antibody (aa1019-1293, clone S55-10) - LS-C109002 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S55-10
IHC analysis of Cav3.2 in frozen sections of mouse brain extract using CACNA1H / Cav3.2 antibody.

Anti-CACNA1H / Cav3.2 Antibody (aa1019-1293, clone S55-10, Atto 488) - LS-C230624 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S55-10

Anti-CACNA1H / Cav3.2 Antibody (aa462-511) - LS-C120466 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts from A549 cells, using CACNA1H Antibody. The lane on the right is treated with the synthesized peptide.

Anti-CACNA1H / Cav3.2 Antibody (aa1019-1293, clone S55-10, Atto 390) - LS-C230621 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S55-10

Anti-CACNA1H / Cav3.2 Antibody (aa1019-1293, clone S55-10, Atto 565) - LS-C230625 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S55-10

Anti-CACNA1H / Cav3.2 Antibody (aa1019-1293, clone S55-10, Atto 594) - LS-C230626 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S55-10

Anti-CACNA1H / Cav3.2 Antibody (aa1019-1293, clone S55-10, Atto 633) - LS-C230627 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S55-10

Anti-CACNA1H / Cav3.2 Antibody (aa1019-1293, clone S55-10, Atto 655) - LS-C230628 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S55-10

Anti-CACNA1H / Cav3.2 Antibody (aa1019-1293, clone S55-10, Atto 680) - LS-C230629 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S55-10

Anti-CACNA1H / Cav3.2 Antibody (aa1019-1293, clone S55-10, Atto 700) - LS-C230630 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S55-10

Anti-CACNA1H / Cav3.2 Antibody (aa1019-1293, clone S55-10, AP) - LS-C230631 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S55-10

Anti-CACNA1H / Cav3.2 Antibody (aa1019-1293, clone S55-10, APC) - LS-C230632 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S55-10

Anti-CACNA1H / Cav3.2 Antibody (aa1019-1293, clone S55-10, Biotin) - LS-C230633 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S55-10
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