| Gene Symbol |
SPAG9
|
| Entrez Gene |
9043
|
| Alt Symbol |
CT89, HLC-6, HLC4, HLC6, JIP-4, JIP4, JLP, PHET, PIG6
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
sperm associated antigen 9
|
| Other Description |
C-Jun-amino-terminal kinase-interacting protein 4|JNK interacting protein|JNK/SAPK-associated protein|Max-binding protein|c-Jun NH2-terminal kinase-associated leucine zipper protein|cancer/testis antigen 89|human lung cancer oncogene 6 protein|lung cancer oncogene 4|mitogen-activated protein kinase 8-interacting protein 4|proliferation-inducing gene 6|protein highly expressed in testis|sperm associated antigen 9 variant 5|sperm surface protein|sunday driver 1
|
| Swissprots |
Q8IZX7 Q3KQU8 Q96II0 Q86WC8 Q9H811 O60905 B4DHH2 Q3MKM7 A8MSX0 O60271 A6H8U5 Q86WC7
|
| Accessions |
EAW94569 EAW94570 EAW94571 EAW94572 EAW94573 EAW94574 O60271 AB011088 BAA25442 AF327452 AAN61565 AF542172 AAQ11383 AK023512 BAG51202 AK024068 BAB14812 AK091921 AK129652 AK295098 BAG58134 AK299553 BAG61498 AK302789 BAG63993 AK307793 AK309214 AY219897 AAO66462 AY219898 AAO66463 AY236487 AAP74807 AY850123 AAX47276 BC007524 AAH07524 BC059946 AAH59946 BC146755 AAI46756 BC153878 AAI53879 DA631864 DC332810 JF432576 ADZ15793 KJ624756 AIC73822 X91879 CAA62987 XM_005257767 XP_005257824 XM_005257768 XP_005257825 XM_005257769 XP_005257826 XM_005257770 XP_005257827 XM_005257771 XP_005257828 XM_005257772 XP_005257829 XM_005257773 XP_005257830 XM_005257774 XP_005257831 XM_006722163 XP_006722226 NM_001130527 NP_001123999 NM_001130528 NP_001124000 NM_001251971 NP_001238900 NM_003971 NP_003962 NM_172345
|
| Function |
The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. Isoform 5 may play a role in spermatozoa-egg- interaction. {ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:15693750}.
|
| Subcellular Location |
Cytoplasm. Cytoplasm, perinuclear region. Note=Perinuclear distribution in response to stress signals such as UV radiation.
|
| Tissue Specificity |
Isoform 5 is expressed only in testis on the round spermatids of stage I, II and II. Isoform 5 is absent in spermatogonia and spermatocyte. Isoform 3 is expressed in testis. Isoform 4 is expressed in testis and in acute myeloid leukemia (AML) patients. {ECO:0000269|PubMed:14662895, ECO:0000269|PubMed:16112646, ECO:0000269|PubMed:9480848}.
|