| Gene Symbol |
CLCA4
|
| Entrez Gene |
22802
|
| Alt Symbol |
CaCC, CaCC2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
chloride channel accessory 4
|
| Other Description |
caCC-2|calcium-activated chloride channel family member 4|calcium-activated chloride channel protein 2|calcium-activated chloride channel regulator 4|chloride channel regulator 4|chloride channel, calcium activated, family member 4|hCLCA4|hCaCC-2
|
| Swissprots |
Q6UX81 Q14CN2 Q9UNF7 A8MQC9 B7Z1Q5
|
| Accessions |
CCQ43402 EAW73184 EAW73185 Q14CN2 AF127035 AAD48398 AK000072 AK000138 BAA90969 AK293766 BAH11591 AK307785 AK307898 AK314430 AY358470 AAQ88834 BC113687 AAI13688 BC113689 AAI13690 CB851641 DA668017 DA761219 HQ258531 ADR83285 XM_011541015 XP_011539317 NM_012128 NP_036260 NR_024602
|
| Function |
May be involved in mediating calcium-activated chloride conductance.
|
| Subcellular Location |
Cell membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Apical cell membrane {ECO:0000250}. Secreted {ECO:0000250}. Note=The C-terminus 30 kDa form is anchored to the membrane. The N-terminus 110 kDa form is released from the membrane triggered by an unknown stimulus. {ECO:0000250}.
|
| Tissue Specificity |
Primarily expressed in the digestive tract, mainly in colon. Detected in smaller amounts in brain, urogenital organs, testis, and salivary and mammary glands. Highly expressed in the epithelial layer and submucosal gland of the inferior turbinate mucosa. Lower levels in the epithelial layer of nasal polyp. {ECO:0000269|PubMed:10437792, ECO:0000269|PubMed:15490240, ECO:0000269|PubMed:16012037}.
|
| Top Pathways |
Olfactory transduction, Pancreatic secretion
|
![Western Blot: CLCA4 Overexpression Lysate (Adult Normal) [NBL1-09229] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for CLCA4.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/1639_CLCA4%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-09229-img0002.jpg)