MAK

Gene Symbol	MAK
Entrez Gene	4117
Alt Symbol	RP62, dJ417M14.2
Species	Human
Gene Type	protein-coding
Description	male germ cell-associated kinase
Other Description	male germ cell-associated kinase retinal-enriched isoform|serine/threonine protein kinase MAK|serine/threonine-protein kinase MAK
Swissprots	Q9NUH7 G1FL29 F1T0K6 Q547D0 P20794
Accessions	AAA36195 EAW55282 EAW55283 EAW55284 EAW55285 P20794 AB593146 BAJ84080 AF505623 AAN16405 AK097831 BAG53538 AK310329 AK314408 BC033002 BC039825 AAH39825 BM704130 BM978645 BP246863 DB082719 JN135248 AEJ36294 JN226411 AEL29206 XM_011514619 XP_011512921 XM_011514620 XP_011512922 XM_011514621 XP_011512923 XM_011514622 XP_011512924 XM_011514623 XP_011512925 XM_011514624 XP_011512926 XR_926215 XR_926216 XR_926217 XR_926219 XR_926220 XR_926221 NM_001242385 NP_001229314 NM_001242957 NP_001229886 NM_005906 NP_005897
Function	Essential for the regulation of ciliary length and required for the long-term survival of photoreceptors (By similarity). Phosphorylates FZR1 in a cell cycle-dependent manner. Plays a role in the transcriptional coactivation of AR. Could play an important function in spermatogenesis. May play a role in chromosomal stability in prostate cancer cells. {ECO:0000250, ECO:0000269|PubMed:12084720, ECO:0000269|PubMed:16951154, ECO:0000269|PubMed:21986944}.
Subcellular Location	Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Midbody. Cell projection, cilium, photoreceptor outer segment {ECO:0000250}. Photoreceptor inner segment. Note=Localized in both the connecting cilia and the outer segment axonemes (By similarity). Localized uniformly in nuclei during interphase, to the mitotic spindle and centrosomes during metaphase and anaphase, and also to midbody at anaphase until telophase. {ECO:0000250}.
Tissue Specificity	Expressed in prostate cancer cell lines at generally higher levels than in normal prostate epithelial cell lines. Isoform 1 is expressed in kidney, testis, lung, trachea, and retina. Isoform 2 is retina-specific where it is expressed in rod and cone photoreceptors. {ECO:0000269|PubMed:12084720, ECO:0000269|PubMed:21825139}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human MAK full length protein - ab190407 from Abcam Category Protein Prices $521.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Human MAK full length protein - ab158852 from Abcam Category Protein Source Wheat germ Species Human

Human MAK protein fragment - ab158853 from Abcam Category Protein Source Wheat germ Species Human

MAK Antibody Blocking Peptide - LS-E9037 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MAK Antibody Blocking Peptide - LS-E15554 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human MAK Protein - H00004117-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

Recombinant Human MAK Protein - H00004117-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

MAK Peptide - P2551 from Novus Biologicals Category Peptide Species Human

MAK-Antibody-C-term-Blocking-Peptide - BP7542b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MAK Blocking Peptide - 33R-9987 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

MAK - H00004117-P01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

MAK - H00004117-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

MAK - H00004117-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

MAK fusion protein - Ag4571 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human MAK, GST-tagged - MAK-712H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human MAK, GST-tagged - MAK-35H from Creative Biomart Category Protein Source Sf9 insect cells using baculovirus Species Human

Recombinant Human Serine/threonine-protein kinase MAK(MAK) - CSB-YP013369HU CSB-EP013369HU CSB-BP013369HU CSB-MP013369HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

MAK Recombinant Protein Antigen - NBP1-85176PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

MAK-Blocking-Peptide-C-term - BP20087b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MAK Peptide, Human - M34GP09118H from Creative Peptides Category Peptide Source Synthetic. Species Human

Serine/threonine-protein kinase MAK (MAK), Recombinant Protein - MBS962058 from MyBioSource Category Protein Prices $1,420.00, $1,420.00, $1,645.00, $1,645.00, $2,400.00, $2,400.00, $2,840.00, $2,840.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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