MAK

Gene Symbol	MAK
Entrez Gene	4117
Alt Symbol	RP62, dJ417M14.2
Species	Human
Gene Type	protein-coding
Description	male germ cell-associated kinase
Other Description	male germ cell-associated kinase retinal-enriched isoform|serine/threonine protein kinase MAK|serine/threonine-protein kinase MAK
Swissprots	Q9NUH7 G1FL29 F1T0K6 Q547D0 P20794
Accessions	AAA36195 EAW55282 EAW55283 EAW55284 EAW55285 P20794 AB593146 BAJ84080 AF505623 AAN16405 AK097831 BAG53538 AK310329 AK314408 BC033002 BC039825 AAH39825 BM704130 BM978645 BP246863 DB082719 JN135248 AEJ36294 JN226411 AEL29206 XM_011514619 XP_011512921 XM_011514620 XP_011512922 XM_011514621 XP_011512923 XM_011514622 XP_011512924 XM_011514623 XP_011512925 XM_011514624 XP_011512926 XR_926215 XR_926216 XR_926217 XR_926219 XR_926220 XR_926221 NM_001242385 NP_001229314 NM_001242957 NP_001229886 NM_005906 NP_005897
Function	Essential for the regulation of ciliary length and required for the long-term survival of photoreceptors (By similarity). Phosphorylates FZR1 in a cell cycle-dependent manner. Plays a role in the transcriptional coactivation of AR. Could play an important function in spermatogenesis. May play a role in chromosomal stability in prostate cancer cells. {ECO:0000250, ECO:0000269|PubMed:12084720, ECO:0000269|PubMed:16951154, ECO:0000269|PubMed:21986944}.
Subcellular Location	Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Midbody. Cell projection, cilium, photoreceptor outer segment {ECO:0000250}. Photoreceptor inner segment. Note=Localized in both the connecting cilia and the outer segment axonemes (By similarity). Localized uniformly in nuclei during interphase, to the mitotic spindle and centrosomes during metaphase and anaphase, and also to midbody at anaphase until telophase. {ECO:0000250}.
Tissue Specificity	Expressed in prostate cancer cell lines at generally higher levels than in normal prostate epithelial cell lines. Isoform 1 is expressed in kidney, testis, lung, trachea, and retina. Isoform 2 is retina-specific where it is expressed in rod and cone photoreceptors. {ECO:0000269|PubMed:12084720, ECO:0000269|PubMed:21825139}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

MAK (H-190) - sc-135298 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

MAK (F-12) - sc-168537 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

MAK (JK-10) - sc-100432 from Santa Cruz Biotechnology Prices $295.00 Sizes 100 µg/ml Host Mouse Clonality Monoclonal

MAK (C-24) - sc-130165 from Santa Cruz Biotechnology Prices $279.00 Sizes 100 µg/ml Host Rabbit Clonality Polyclonal

Anti-MAK (phospho Y159) antibody - ab92562 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-MAK antibody - ab80536 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-MAK antibody - ab137281 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-MAK antibody - ab55453 from Abcam Prices $370.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-MAK Antibody (aa595-623, AP) - LS-C262466 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MAK Antibody (aa595-623, APC) - LS-C262467 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MAK Antibody (C-Terminus) - LS-C80489 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-MAK Antibody (aa595-623, Biotin) - LS-C262468 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MAK Antibody (aa126-175) - LS-C199210 from LifeSpan Bioscience Prices $315.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-MAK Antibody (aa595-623, FITC) - LS-C262469 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MAK Antibody (aa595-623, Azide-free, HRP) - LS-C262470 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MAK Antibody (aa595-623, PE) - LS-C262471 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MAK Antibody (phospho-Tyr159) - LS-C199211 from LifeSpan Bioscience Prices $315.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-MAK Antibody (aa595-623) - LS-C157875 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-MAK Antibody (C-Terminus, AP) - LS-C279116 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MAK Antibody (C-Terminus, PE) - LS-C279122 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MAK Antibody (C-Terminus, FITC) - LS-C279119 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MAK Antibody (C-Terminus, Biotin) - LS-C279118 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MAK Antibody (C-Terminus, APC) - LS-C279117 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MAK Antibody (C-Terminus, Azide-free, HRP) - LS-C279120 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-MAK Antibody - LS-C311359 from LifeSpan Bioscience Prices $475.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

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