Gene Symbol |
VBP1
|
Entrez Gene |
7411
|
Alt Symbol |
HIBBJ46, PFD3, PFDN3, VBP-1
|
Species |
Human
|
Gene Type |
protein-coding
|
Description |
von Hippel-Lindau binding protein 1
|
Other Description |
VHL binding protein-1|prefoldin subunit 3
|
Swissprots |
Q86X96 Q5JT81 B2R8L5 P61758 O55228 Q15765
|
Accessions |
CAI41469 EAW72627 EAW72628 EAW72629 EAW72630 P61758 AA626259 AA781721 AK301646 BAG63125 AK313420 BAG36212 BC009570 BC040002 BC046094 AAH46094 BG575380 BT019604 AAV38411 CR541932 CAG46730 DA610631 U56833 AAC50617 U96759 AAC23907 Y17394 CAA76761 NM_001303543 NP_001290472 NM_001303544 NP_001290473 NM_001303545 NP_001290474 NM_003372 NP_003363
|
Function |
Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. {ECO:0000269|PubMed:9630229}.
|
Subcellular Location |
Cytoplasm. Nucleus. Note=In complex with VHL can translocate to the nucleus.
|
Tissue Specificity |
Ubiquitous.
|