| Gene Symbol |
RAI1
|
| Entrez Gene |
10743
|
| Alt Symbol |
SMCR, SMS
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
retinoic acid induced 1
|
| Other Description |
Smith-Magenis syndrome chromosome region|retinoic acid-induced protein 1
|
| Swissprots |
Q96JK5 Q8WU64 Q8ND08 Q7Z5J4 Q9UF69 Q9H1C1 Q9H1C2 Q8N3B4
|
| Accessions |
CAC20424 EAW55692 EAW55693 EAW55694 EAW55695 EAW55696 Q7Z5J4 AB058723 BAB47449 AJ230819 AJ271790 CAC20423 AL133649 CAB63768 AL834468 CAD39127 AL834486 CAD39144 AY172136 AAO31738 BC021209 AAH21209 NM_030665 NP_109590
|
| Function |
Transcriptional regulator of the circadian clock components: CLOCK, ARNTL/BMAL1, ARNTL2/BMAL2, PER1/3, CRY1/2, NR1D1/2 and RORA/C. Positively regulates the transcriptional activity of CLOCK a core component of the circadian clock. Regulates transcription through chromatin remodeling by interacting with other proteins in chromatin as well as proteins in the basic transcriptional machinery. May be important for embryonic and postnatal development. May be involved in neuronal differentiation. {ECO:0000269|PubMed:22578325}.
|
| Subcellular Location |
Cytoplasm. Nucleus. Note=In neurons, localized to neurites. {ECO:0000250}.
|
| Tissue Specificity |
Expressed in all tissues examined with higher expression in the heart and brain. No expression was seen in the corpus callosum of the brain. {ECO:0000269|PubMed:12837267}.
|