Gene Symbol | RAI1 |
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Entrez Gene | 10743 |
Alt Symbol | SMCR, SMS |
Species | Human |
Gene Type | protein-coding |
Description | retinoic acid induced 1 |
Other Description | Smith-Magenis syndrome chromosome region|retinoic acid-induced protein 1 |
Swissprots | Q96JK5 Q8WU64 Q8ND08 Q7Z5J4 Q9UF69 Q9H1C1 Q9H1C2 Q8N3B4 |
Accessions | CAC20424 EAW55692 EAW55693 EAW55694 EAW55695 EAW55696 Q7Z5J4 AB058723 BAB47449 AJ230819 AJ271790 CAC20423 AL133649 CAB63768 AL834468 CAD39127 AL834486 CAD39144 AY172136 AAO31738 BC021209 AAH21209 NM_030665 NP_109590 |
Function | Transcriptional regulator of the circadian clock components: CLOCK, ARNTL/BMAL1, ARNTL2/BMAL2, PER1/3, CRY1/2, NR1D1/2 and RORA/C. Positively regulates the transcriptional activity of CLOCK a core component of the circadian clock. Regulates transcription through chromatin remodeling by interacting with other proteins in chromatin as well as proteins in the basic transcriptional machinery. May be important for embryonic and postnatal development. May be involved in neuronal differentiation. {ECO:0000269|PubMed:22578325}. |
Subcellular Location | Cytoplasm. Nucleus. Note=In neurons, localized to neurites. {ECO:0000250}. |
Tissue Specificity | Expressed in all tissues examined with higher expression in the heart and brain. No expression was seen in the corpus callosum of the brain. {ECO:0000269|PubMed:12837267}. |
RAI1 CRISPR/Cas9 KO Plasmid (h) - sc-407674 from Santa Cruz Biotechnology
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RAI1 HDR Plasmid (h) - sc-407674-HDR from Santa Cruz Biotechnology
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RAI1 Double Nickase Plasmid (h) - sc-407674-NIC from Santa Cruz Biotechnology
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RAI1 Double Nickase Plasmid (h2) - sc-407674-NIC-2 from Santa Cruz Biotechnology
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RAI1 CRISPR Activation Plasmid (h) - sc-407674-ACT from Santa Cruz Biotechnology
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RAI1 CRISPR Activation Plasmid (h2) - sc-407674-ACT-2 from Santa Cruz Biotechnology
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RAI1 Lentiviral Activation Particles (h) - sc-407674-LAC from Santa Cruz Biotechnology
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RAI1 Lentiviral Activation Particles (h2) - sc-407674-LAC-2 from Santa Cruz Biotechnology
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RAI1 siRNA (h) - sc-61438 from Santa Cruz Biotechnology
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RAI1 shRNA Plasmid (h) - sc-61438-SH from Santa Cruz Biotechnology
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RAI1 shRNA (h) Lentiviral Particles - sc-61438-V from Santa Cruz Biotechnology
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Spermine synthase RNAi - H00006611-R01 from Novus Biologicals
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RAI1 RNAi - H00010743-R01 from Novus Biologicals
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MISSION® esiRNA - EHU058941 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17918 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17918 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09475 from Sigma-Aldrich
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RAI1 siRNA (Human) - CRH7320 from Cohesion Biosciences
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RAI1 - MBS8227201 from MyBioSource
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shRNA set against Human RAI1(NM_030665.3) - SHR162762 from Creative biogene
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Human RAI1 siRNA - orb267822 from Biorbyt
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RAI1 shRNA Plasmid (Human) - CHH7320 from Cohesion Biosciences
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RAI1 miRNA 3'UTR clone - MiUTR1H-08607 from Creative biogene
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