| Gene Symbol |
LHX3
|
| Entrez Gene |
8022
|
| Alt Symbol |
CPHD3, LIM3, M2-LHX3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
LIM homeobox 3
|
| Other Description |
LIM homeobox protein 3|LIM/homeobox protein Lhx3|LIM/homeodomain protein LHX3
|
| Swissprots |
Q9P0I9 Q5TB40 Q9UBR4 Q9P0I8 Q9NZB5 Q5TB39
|
| Accessions |
AAF26412 AAG10399 AAL26314 EAW88205 EAW88206 Q9UBR4 AB593062 BAJ84009 AB593063 BAJ84010 AB593064 BAJ84011 AB593065 BAJ84012 AB593066 BAJ84013 AB593067 BAJ84014 AF096169 AAF17292 AF156888 AAF36808 AF156889 AAF36809 BC152818 AAI52819 BC156735 AAI56736 BM665174 BM799949 BU165468 XM_005263410 XP_005263467 NM_014564 NP_055379 NM_178138 NP_835258
|
| Function |
Acts as a transcriptional activator. Binds to and activates the promoter of the alpha-glycoprotein gene, and synergistically enhances transcription from the prolactin promoter in cooperation with POU1F1/Pit-1 (By similarity). Required for the establishment of the specialized cells of the pituitary gland and the nervous system. Involved in the development of interneurons and motor neurons in cooperation with LDB1 and ISL1. {ECO:0000250, ECO:0000269|PubMed:21149718}.
|
| Subcellular Location |
Nucleus {ECO:0000305}.
|
![Western Blot: LHX3 Overexpression Lysate (Adult Normal) [NBL1-12515] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for LHX3.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/10312_LHX3%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBL1-12515-img0002.jpg)