Gene Symbol | LHX3 |
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Entrez Gene | 8022 |
Alt Symbol | CPHD3, LIM3, M2-LHX3 |
Species | Human |
Gene Type | protein-coding |
Description | LIM homeobox 3 |
Other Description | LIM homeobox protein 3|LIM/homeobox protein Lhx3|LIM/homeodomain protein LHX3 |
Swissprots | Q9P0I9 Q5TB40 Q9UBR4 Q9P0I8 Q9NZB5 Q5TB39 |
Accessions | AAF26412 AAG10399 AAL26314 EAW88205 EAW88206 Q9UBR4 AB593062 BAJ84009 AB593063 BAJ84010 AB593064 BAJ84011 AB593065 BAJ84012 AB593066 BAJ84013 AB593067 BAJ84014 AF096169 AAF17292 AF156888 AAF36808 AF156889 AAF36809 BC152818 AAI52819 BC156735 AAI56736 BM665174 BM799949 BU165468 XM_005263410 XP_005263467 NM_014564 NP_055379 NM_178138 NP_835258 |
Function | Acts as a transcriptional activator. Binds to and activates the promoter of the alpha-glycoprotein gene, and synergistically enhances transcription from the prolactin promoter in cooperation with POU1F1/Pit-1 (By similarity). Required for the establishment of the specialized cells of the pituitary gland and the nervous system. Involved in the development of interneurons and motor neurons in cooperation with LDB1 and ISL1. {ECO:0000250, ECO:0000269|PubMed:21149718}. |
Subcellular Location | Nucleus {ECO:0000305}. |
LHX3 CRISPR/Cas9 KO Plasmid (h) - sc-404482 from Santa Cruz Biotechnology
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LHX3 HDR Plasmid (h) - sc-404482-HDR from Santa Cruz Biotechnology
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LHX3 Double Nickase Plasmid (h) - sc-404482-NIC from Santa Cruz Biotechnology
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LHX3 Double Nickase Plasmid (h2) - sc-404482-NIC-2 from Santa Cruz Biotechnology
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LHX3 CRISPR Activation Plasmid (h) - sc-404482-ACT from Santa Cruz Biotechnology
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LHX3 CRISPR Activation Plasmid (h2) - sc-404482-ACT-2 from Santa Cruz Biotechnology
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LHX3 Lentiviral Activation Particles (h) - sc-404482-LAC from Santa Cruz Biotechnology
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LHX3 Lentiviral Activation Particles (h2) - sc-404482-LAC-2 from Santa Cruz Biotechnology
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LHX3 siRNA (h) - sc-38712 from Santa Cruz Biotechnology
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LHX3 shRNA Plasmid (h) - sc-38712-SH from Santa Cruz Biotechnology
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LHX3 shRNA (h) Lentiviral Particles - sc-38712-V from Santa Cruz Biotechnology
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LHX3 RNAi - H00008022-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN11694 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11694 from Sigma-Aldrich
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LHX3 siRNA (Human) - CRH5342 from Cohesion Biosciences
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LHX3 RNAi - H00008022-R02 from Novus Biologicals
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LHX3 CRISPR/Cas9 KO Plasmid (h2) - sc-404482-KO-2 from Santa Cruz Biotechnology
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LHX3 HDR Plasmid (h2) - sc-404482-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human LHX3 (NM_178138.4) - SHH330119 from Creative biogene
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Human LHX3 siRNA - orb265844 from Biorbyt
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LHX3 shRNA Plasmid (Human) - CHH5342 from Cohesion Biosciences
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