RHOA
| Gene Symbol | RHOA |
|---|---|
| Entrez Gene | 387 |
| Alt Symbol | ARH12, ARHA, RHO12, RHOH12 |
| Species | Human |
| Gene Type | protein-coding |
| Description | ras homolog family member A |
| Other Description | Aplysia ras-related homolog 12|h12|oncogene RHO H12|ras homolog gene family, member A|rho cDNA clone 12|small GTP binding protein RhoA|transforming protein RhoA |
| Swissprots | Q9UDJ0 Q53HM4 Q5U024 Q9UEJ4 P06749 P61586 |
| Accessions | AAA67539 CAL40338 EAW64978 EAW64979 EAW64980 P61586 AF498970 AAM21117 AK130066 AK130808 AK222556 BAD96276 AK296654 BAG59251 AK307220 BC000946 AAH00946 BC001360 AAH01360 BC005976 AAH05976 BT019870 AAV38673 BX647063 CAE46190 EU831594 ACE87194 EU831679 ACE86513 L09159 AAA50612 L25080 AAC33178 LN607834 CEF49521 X05026 CAA28690 XM_011533695 XP_011531997 NM_001664 NP_001655 |
| Function | Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. Stimulates PKN2 kinase activity. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA- DIAPH1 signaling pathway plays an important role in ERBB2- dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membr |
| Subcellular Location | Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, cytoskeleton. Cleavage furrow. Cytoplasm, cell cortex {ECO:0000269|PubMed:9635436}. Midbody. Cell projection, lamellipodium {ECO:0000250}. Note=Localized to cell-cell contacts in calcium-treated keratinocytes (By similarity). Translocates to the equatorial region before furrow formation in a ECT2-dependent manner. Localizes to the equatorial cell cortex (at the site of the presumptive furrow) in early anaphase in a activated form and in a myosin- and actin-independent manner. {ECO:0000250}. |
| Top Pathways | cGMP-PKG signaling pathway, Oxytocin signaling pathway, cAMP signaling pathway, Rap1 signaling pathway, MicroRNAs in cancer |
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