RHOA

Gene Symbol RHOA
Entrez Gene 387
Alt Symbol ARH12, ARHA, RHO12, RHOH12
Species Human
Gene Type protein-coding
Description ras homolog family member A
Other Description Aplysia ras-related homolog 12|h12|oncogene RHO H12|ras homolog gene family, member A|rho cDNA clone 12|small GTP binding protein RhoA|transforming protein RhoA
Swissprots Q9UDJ0 Q53HM4 Q5U024 Q9UEJ4 P06749 P61586
Accessions AAA67539 CAL40338 EAW64978 EAW64979 EAW64980 P61586 AF498970 AAM21117 AK130066 AK130808 AK222556 BAD96276 AK296654 BAG59251 AK307220 BC000946 AAH00946 BC001360 AAH01360 BC005976 AAH05976 BT019870 AAV38673 BX647063 CAE46190 EU831594 ACE87194 EU831679 ACE86513 L09159 AAA50612 L25080 AAC33178 LN607834 CEF49521 X05026 CAA28690 XM_011533695 XP_011531997 NM_001664 NP_001655
Function Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotuberculosis, which causes gastrointestinal disorders. Stimulates PKN2 kinase activity. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA- DIAPH1 signaling pathway plays an important role in ERBB2- dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membr
Subcellular Location Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, cytoskeleton. Cleavage furrow. Cytoplasm, cell cortex {ECO:0000269|PubMed:9635436}. Midbody. Cell projection, lamellipodium {ECO:0000250}. Note=Localized to cell-cell contacts in calcium-treated keratinocytes (By similarity). Translocates to the equatorial region before furrow formation in a ECT2-dependent manner. Localizes to the equatorial cell cortex (at the site of the presumptive furrow) in early anaphase in a activated form and in a myosin- and actin-independent manner. {ECO:0000250}.
Top Pathways cGMP-PKG signaling pathway, Oxytocin signaling pathway, cAMP signaling pathway, Rap1 signaling pathway, MicroRNAs in cancer

RhoA (67B9) Rabbit mAb - 2117 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone 67B9
Western blot analysis of extracts from various cell lines, using RhoA (67B9) Rabbit mAb.

Rho A (119) - sc-179 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Western blot analysis of Rho A expression in A-431 (A), HeLa (B) and KNRK (C) whole cell lysates. Antibodies tested include Rho A (119): sc-179 (A) and Rho A (26C4): sc-418 (B,C).

Rho A (26C4) - sc-418 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Rho A (26C4): sc-418. Immunofluorescence staining of methanol-fixed NIH/3T3 cells showing cytoplasmic localization.

Rho A (C-15) - sc-32039 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Rho A (F-1) - sc-166399 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Rho A (F-1): sc-166399. Western blot analysis of Rho C expression in non-transfected: sc-117752 (A) and mouse Rho C transfected: sc-123119 (B) 293T whole cell lysates.

Rho A/B/C (H-70) - sc-28565 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Rho A/B/C (H-70): sc-28565. Western blot analysis of Rho A, Rho B and Rho C expression in PC-12 whole cell lysate.

Rho A/B/C (P-16) - sc-32040 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

p-Rho A (Ser 188) - sc-32954 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
p-Rho A (Ser 188): sc-32954. Western blot analysis of Rho A phosphorylation in untreated (A) and lambda protein phosphatase treated (B) mouse brain tissue extracts.

Anti-E. coli H-12 antibody - ab79001 from Abcam

Prices $370.00
Sizes 5 ml
Host Rabbit
Clonality Polyclonal

Anti-Rho A + B + C antibody [EPR18299] - ab188103 from Abcam

Prices $99.00, $347.00
Sizes 10 µl, 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR18299
All lanes : Anti-Rho A + B + C antibody [EPR18299] (ab188103) at 1/20000 dilutionLane 1 : Human RhoA full length proteinLane 2 : Human RhoB full length proteinLysates/proteins at 0.01 µg per lane.SecondaryGoat Anti-Rabbit IgG, (H+L),Peroxidase conjugated at 1/1000 dilution

Anti-Rho antibody - ab66124 from Abcam

Prices $370.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Rho antibody (ab66124) at 1/500 dilutionLane 1 : MCF7 Cell Lysate with immunising peptideLane 2 : MCF7 Cell LysateLysates/proteins at 10 µg per lane.

Anti-Rho antibody [EP487Y] - ab40673 from Abcam

Prices $368.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP487Y
All lanes : Anti-Rho antibody [EP487Y] (ab40673) at 1/1000 dilution (purified)Lane 1 : A431 cell lysateLane 2 : MCF7 cell lysateLane 3 : HeLa cell lysateLane 4 : K562 cell lysateLane 5 : Jurkat cell lysateLysates/proteins at 20 µg per lane.SecondaryHRP goat anti-rabbit (H+L) at 1/1000 dilution

Anti-Rho antibody [Y486] - ab32046 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone Y486
Anti-Rho antibody [Y486] (ab32046) at 1/2000 dilution + PC12 cell lysate

Anti-RhoA + C antibody [1B34A10] - ab175359 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1B34A10
All lanes : Anti-RhoA + C antibody [1B34A10] (ab175359) at 1/1000 dilutionLane 1 : HeLa whole cell lysate at 25 µgLane 2 : A431 whole cell lysate at 25 µgLane 3 : HEK293T whole cell lysate at 25 µgLane 4 : U2 OS whole cell lysate at 25 µgLane 5 : NIH 3T3 whole cell lysate at 25 µgLane 6 : K562 whole cell lysate at 25 µgLane 7 : RhoA purified protein at 0.5 µgLane 8 : RhoB purified protein at 0.5 µgLane 9 : RhoC purified protein with proprietary tag at 0.5 µgSecondarygoat anti-mouse IgG-HRP at 1/15000 dilutiondeveloped using the ECL technique

Anti-RhoA (phospho S188) antibody - ab125275 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab125275 staining RhoA (phospho S188) in mouse spinal cord tissue sections by Immunohistochemistry (IHC-Fr - frozen sections). Tissue was fixed with formaldehyde, permeabilized with citrate buffer and blocked with 5% serum for 1 hour at 25°C. Samples were incubated with primary antibody (5µg/ml) for 16 hours at 4°C. An Alexa Fluor® 568-conjugated goat anti-rabbit IgG polyclonal (1/200) was used as the secondary antibody.See Abreview

Anti-RhoA (phospho S188) antibody - ab41435 from Abcam

Prices $387.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Lanes 1 - 2 : anti-RhoLanes 3 - 6 : Anti-RhoA (phospho S188) antibody (ab41435) at 1/1000 dilutionLane 1 : recombinant human RhoA GST fusion protein, unphosphorylated Lane 2 : recombinant human RhoA GST fusion protein, phosphorylated with PKA Lane 3 : recombinant human RhoA GST fusion protein, unphosphorylatedLane 4 : recombinant human RhoA GST fusion protein, phosphorylated with PKA Lane 5 : recombinant human RhoA GST fusion protein, phosphorylated with PKA with RhoA (phospho S188) peptide Lane 6 : recombinant human RhoA GST fusion protein, phosphorylated with PKA with non-specific phosphoserine peptide

Anti-RhoA (phospho S188) antibody - ab192187 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-RhoA (phospho S188) antibody (ab192187) at 1/500 dilutionLane 1 : HeLa whole cell lysate with antigen-specific peptideLane 2 : HeLa whole cell lysateLysates/proteins at 12.5 µg per lane.

Anti-RhoA antibody - ab130442 from Abcam

Host Chicken
Clonality Polyclonal

Anti-RhoA antibody - ab63607 from Abcam

Host Rabbit
Clonality Polyclonal
ab63607, at a 1/50 dilution, staining human RhoA in paraffin-embedded breast carcinoma tissue by Immunohistochemistry, with (+) or without (-) immunising peptide.

Anti-RhoA antibody - ab167551 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-RhoA antibody (ab167551) at 1 µg/mlLane 1 : RhoA transfected 293T cell line lysateLane 2 : Non-transfected 293T cell line lysateLysates/proteins at 15 µl per lane.

Anti-RhoA antibody [1B12] - ab54835 from Abcam

Prices $403.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1B12
ab54835 at 10 ug/ml staining RhoA in human Hela cells (ab150035) by Immunocytochemistry / Immunofluorescence.

Anti-RhoA antibody [1C1] - ab124287 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 1C1
ab124287, at 5 µg/ml, staining RhoA in paraffin embedded Human breast tissue by Immunohistochemistry.

Anti-RHOA Antibody (aa1-155) - LS-C17685 from LifeSpan Bioscience

Prices $455.00
Sizes 200 µg
Host Mouse
Clonality Monoclonal

Anti-RHOA Antibody (aa100-150) - LS-C94742 from LifeSpan Bioscience

Prices $325.00
Sizes 500 µg
Host Rabbit
Clonality Polyclonal

Anti-RHOA Antibody - LS-C94744 from LifeSpan Bioscience

Prices $325.00
Sizes 500 µg
Host Sheep
Clonality Polyclonal
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