| Gene Symbol |
PPIP5K1
|
| Entrez Gene |
9677
|
| Alt Symbol |
HISPPD2A, IP6K, IPS1, VIP1, hsVIP1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
diphosphoinositol pentakisphosphate kinase 1
|
| Other Description |
IP6 kinase|VIP1 homolog|histidine acid phosphatase domain containing 2A|histidine acid phosphatase domain-containing protein 2A|inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1|inositol pyrophosphate synthase 1|insP6 and PP-IP5 kinase 1
|
| Swissprots |
O15082 Q8IZN0 Q86XW8 Q6PFW1 Q86UV3 Q7Z3A7 Q86TE7 Q86UV4 Q5HYF8
|
| Accessions |
EAW92609 Q6PFW1 AB002375 BAA20831 AF502586 AAP30842 AF502587 AAP30843 AF502588 AAP30844 AF502589 AAP30845 AF543190 AAN40768 AI214309 AI638651 AI656736 AK307438 BC035611 BC050263 AAH50263 BC057395 AAH57395 BX538022 CAD97968 BX647814 CAI46011 BX647870 DB065605 DB228266 DQ102768 AAZ78114 XM_005254803 XP_005254860 XM_005254804 XP_005254861 XM_006720786 XP_006720849 XM_011522249 XP_011520551 XM_011522250 XP_011520552 XM_011522251 XP_011520553 XM_011522252 XP_011520554 XM_011522253 XP_011520555 XM_011522254 XP_011520556 XM_011522255 XP_011520557 XM_011522256 XP_011520558 XM_011522257 XP_011520559 XM_011522258 XP_011520560 XM_011522259 XP_011520561 NM_001130858 NP_001124330 NM_001130859 NP_001124331 NM_001190214 NP_001177143 NM_014659 NP_055474 NM_001024463
|
| Function |
Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis- diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates inositol hexakisphosphate (InsP6) at positions 1 or 3 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates at position 1 or 3 PP-InsP5, produced by IP6Ks from InsP6, to produce (PP)2-InsP4. Activated when cells are exposed to hyperosmotic stress. {ECO:0000269|PubMed:17412958, ECO:0000269|PubMed:17690096, ECO:0000269|PubMed:17702752}.
|
| Subcellular Location |
Cytoplasm, cytosol. Cell membrane. Note=Relocalizes to the plasma membrane upon activation of the PtdIns 3-kinase pathway.
|
| Tissue Specificity |
Widely expressed, with a higher expression in skeletal muscle, heart and brain. {ECO:0000269|PubMed:17690096}.
|