PPIP5K1

Gene Symbol PPIP5K1
Entrez Gene 9677
Alt Symbol HISPPD2A, IP6K, IPS1, VIP1, hsVIP1
Species Human
Gene Type protein-coding
Description diphosphoinositol pentakisphosphate kinase 1
Other Description IP6 kinase|VIP1 homolog|histidine acid phosphatase domain containing 2A|histidine acid phosphatase domain-containing protein 2A|inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1|inositol pyrophosphate synthase 1|insP6 and PP-IP5 kinase 1
Swissprots O15082 Q8IZN0 Q86XW8 Q6PFW1 Q86UV3 Q7Z3A7 Q86TE7 Q86UV4 Q5HYF8
Accessions EAW92609 Q6PFW1 AB002375 BAA20831 AF502586 AAP30842 AF502587 AAP30843 AF502588 AAP30844 AF502589 AAP30845 AF543190 AAN40768 AI214309 AI638651 AI656736 AK307438 BC035611 BC050263 AAH50263 BC057395 AAH57395 BX538022 CAD97968 BX647814 CAI46011 BX647870 DB065605 DB228266 DQ102768 AAZ78114 XM_005254803 XP_005254860 XM_005254804 XP_005254861 XM_006720786 XP_006720849 XM_011522249 XP_011520551 XM_011522250 XP_011520552 XM_011522251 XP_011520553 XM_011522252 XP_011520554 XM_011522253 XP_011520555 XM_011522254 XP_011520556 XM_011522255 XP_011520557 XM_011522256 XP_011520558 XM_011522257 XP_011520559 XM_011522258 XP_011520560 XM_011522259 XP_011520561 NM_001130858 NP_001124330 NM_001130859 NP_001124331 NM_001190214 NP_001177143 NM_014659 NP_055474 NM_001024463
Function Bifunctional inositol kinase that acts in concert with the IP6K kinases IP6K1, IP6K2 and IP6K3 to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis- diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, exocytosis, insulin signaling and neutrophil activation. Phosphorylates inositol hexakisphosphate (InsP6) at positions 1 or 3 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates at position 1 or 3 PP-InsP5, produced by IP6Ks from InsP6, to produce (PP)2-InsP4. Activated when cells are exposed to hyperosmotic stress. {ECO:0000269|PubMed:17412958, ECO:0000269|PubMed:17690096, ECO:0000269|PubMed:17702752}.
Subcellular Location Cytoplasm, cytosol. Cell membrane. Note=Relocalizes to the plasma membrane upon activation of the PtdIns 3-kinase pathway.
Tissue Specificity Widely expressed, with a higher expression in skeletal muscle, heart and brain. {ECO:0000269|PubMed:17690096}.

HISPPD2A CRISPR/Cas9 KO Plasmid (h) - sc-407605 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

HISPPD2A HDR Plasmid (h) - sc-407605-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HISPPD2A Double Nickase Plasmid (h) - sc-407605-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HISPPD2A Double Nickase Plasmid (h2) - sc-407605-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HISPPD2A CRISPR Activation Plasmid (h) - sc-407605-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

HISPPD2A CRISPR Activation Plasmid (h2) - sc-407605-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

HISPPD2A Lentiviral Activation Particles (h) - sc-407605-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HISPPD2A Lentiviral Activation Particles (h2) - sc-407605-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

HISPPD2A siRNA (h) - sc-90149 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

HISPPD2A shRNA Plasmid (h) - sc-90149-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

HISPPD2A shRNA (h) Lentiviral Particles - sc-90149-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® Human Phosphatase - SIHP0246 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 250 pmol

MISSION® Human Phosphatase - SIHP0244 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 250 pmol

MISSION® Human Phosphatase - SIHP0964 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 250 pmol

MISSION® Human Phosphatase - SIHP0963 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 250 pmol

MISSION® Human Phosphatase - SIHP0245 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 250 pmol

CompoZr® Knockout ZFN Kit - CKOZFN17237 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17237 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

PPIP5K1 siRNA (Human) - CRH6450 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

PPIP5K1 shRNA Plasmid (Human) - CHH6450 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

PPIP5K1 miRNA 3'UTR clone - MiUTR3H-11584 from Creative biogene

Species Reactivities Human

PPIP5K1 miRNA 3'UTR clone - MiUTR3H-11585 from Creative biogene

Species Reactivities Human

PPIP5K1 miRNA 3'UTR clone - MiUTR3H-11586 from Creative biogene

Species Reactivities Human
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