| Gene Symbol |
ZDHHC17
|
| Entrez Gene |
23390
|
| Alt Symbol |
HIP14, HIP3, HSPC294, HYPH
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
zinc finger, DHHC-type containing 17
|
| Other Description |
DHHC-17|HIP-14|HIP-3|Huntingtin interacting protein H|huntingtin interacting protein 14|huntingtin interacting protein 3|huntingtin yeast partner H|huntingtin-interacting protein 14|huntingtin-interacting protein 3|huntingtin-interacting protein H|palmitoyltransferase ZDHHC17|putative MAPK-activating protein PM11|putative NF-kappa-B-activating protein 205|zinc finger DHHC domain-containing protein 17|zinc finger, DHHC domain containing 17
|
| Swissprots |
B4DR39 Q9P088 O75407 Q8IUH5 Q7Z2I0 Q9UPZ8 Q86W89 Q86YK0
|
| Accessions |
EAW97331 EAW97332 EAW97333 EAW97334 EAW97335 Q8IUH5 AB023163 BAA76790 AB024494 BAC22089 AB097013 BAC77366 AB097035 BAC77388 AF049612 AAC26848 AF161412 AAF28972 AK292866 BAF85555 AK299089 BAG61151 BC030990 AAH30990 BC050324 AAH50324 DA227374 XM_005268749 XP_005268806 XM_005268750 XP_005268807 XM_005268751 XP_005268808 XM_011538083 XP_011536385 XM_011538084 XP_011536386 XR_944512 NM_015336 NP_056151
|
| Function |
Palmitoyltransferase specific for a subset of neuronal proteins, including SNAP25, DLG4/PSD95, GAD2, SYT1 and HD. Palmitoylates MPP1 in erythrocytes. May be involved in the sorting or targeting of critical proteins involved in the initiating events of endocytosis at the plasma membrane. Has transforming activity. Mediates Mg(2+) transport. {ECO:0000269|PubMed:12393793, ECO:0000269|PubMed:15489887, ECO:0000269|PubMed:15603740, ECO:0000269|PubMed:18794299, ECO:0000269|PubMed:19139280, ECO:0000269|PubMed:22496366}.
|
| Subcellular Location |
Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note=Low extracellular Mg(2+) induces increase in Golgi and in post-Golgi membrane vesicles.
|
| Tissue Specificity |
Expressed in all brain regions. Expression is highest in the cortex, cerebellum, occipital lobe and caudate and lowest in the spinal cord. Expression is also seen in testis, pancreas, heart and kidney. ZDHHC17 is the only palmitoyltransferase in erythrocytes. {ECO:0000269|PubMed:12393793, ECO:0000269|PubMed:22496366}.
|
![Western Blot: ZDHHC17 Overexpression Lysate (Adult Normal) [NBL1-18003] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for ZDHHC17.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/6803_ZDHHC17%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-18003-img0002.jpg)