CCKBR

Gene Symbol CCKBR
Entrez Gene 887
Alt Symbol CCK-B, CCK2R, GASR
Species Human
Gene Type protein-coding
Description cholecystokinin B receptor
Other Description CCK-B receptor|CCK-BR|CCK2 receptor|CCK2-R|cholecystokinin-2 receptor|gastrin receptor|gastrin/cholecystokinin type B receptor
Swissprots Q9UBV1 Q96LC6 Q9NYK7 O75824 P32239 Q16144 A8K7P9 Q92492
Accessions AAC37528 AAD14956 BAA04759 EAW68734 EAW68735 P32239 AF239668 AAF67174 AF441129 AAN32829 AK226020 AK292064 BAF84753 AK314266 AY029770 AAK38351 AY322551 AAP84364 BC000740 AAH00740 BT006789 AAP35435 CX762706 D13305 BAA02564 DA297178 DQ335648 ABC86718 DQ335649 ABC86719 DQ335650 ABC86720 DQ335651 ABC86721 DQ890577 ABM92194 DQ893737 ABM84663 L04473 AAA35660 L07746 AAA91831 L08112 AAA35657 S70057 AAB30766 S76072 AAB33740 Y13464 XM_005253210 XP_005253267 XM_011520443 XP_011518745 NM_176875 NP_795344
Function Receptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Subcellular Location Cell membrane; Multi-pass membrane protein.
Tissue Specificity Isoform 1 is expressed in brain, pancreas, stomach, the colon cancer cell line LoVo and the T-lymphoblastoma Jurkat, but not in heart, placenta, liver, lung, skeletal muscle, kidney or the stomach cancer cell line AGS. Expressed at high levels in the small cell lung cancer cell line NCI-H510, at lower levels in NCI-H345, NCI-H69 and GLC-28 cell lines, not expressed in GLC-19 cell line. Within the stomach, expressed at high levels in the mucosa of the gastric fundus and at low levels in the antrum and duodenum. Isoform 2 is present in pancreatic cancer cells and colorectal cancer cells, but not in normal pancreas or colonic mucosa. Isoform 3 is expressed in brain, pancreas, stomach, the stomach cancer cell line AGS and the colon cancer cell line LoVo. {ECO:0000269|PubMed:10913157, ECO:0000269|PubMed:12429993, ECO:0000269|PubMed:7848914, ECO:0000269|PubMed:7887934, ECO:0000269|PubMed:8185170, ECO:0000269|PubMed:8349705}.
Top Pathways Calcium signaling pathway, Gastric acid secretion, Neuroactive ligand-receptor interaction

CCK-BR (C-18) - sc-16177 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CCK-BR (C-18): sc-16177. Western blot analysis of CCK-BR expression in mouse brain tissue extract.

CCK-BR (E-3) - sc-166690 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CCK-BR (E-3): sc-166690. Western blot analysis of CCK-BR expression in SK-N-MC (A), IMR-32 (B) and H4 (C) whole cell lysates and mouse brain (D) and rat heart (E) tissue extracts.

CCK-BR (4A5) - sc-53522 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CCK-BR (4A5): sc-53522. Immunoperoxidase staining of formalin fixed, paraffin-embedded human lower stomach tissue showing cytoplasmic staining of glandular cells.

CCK-BR (H-85) - sc-33221 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
CCK-BR (H-85): sc-33221. Western blot analysis of CCK-BR expression in mouse brain tissue extract.

CCK-BR (S-20) - sc-16176 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-CCKBR antibody - ab183124 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue labeling CCKBR with ab183124 at 1/75 dilution. The image on the right is treated with the synthesized peptide. (Original magnification: X 200)

Anti-CCKBR antibody - ab137495 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-CCKBR antibody (ab137495) at 1/1000 dilutionLane 1 : A431 whole cell lysateLane 2 : H1299 whole cell lysateLane 3 : HeLa whole cell lysateLysates/proteins at 30 µg per lane.

Anti-CCKBR antibody - ab43404 from Abcam

Prices $359.00
Sizes 100 µl
Host Mouse
Clonality Polyclonal
All lanes : Anti-CCKBR antibody (ab43404) at 1/1000 dilutionLane 1 : Total protein extract from E coli with ~50ng to 100ng of an a tagged fusion protein of an irrelevant antigenLane 2 : Total protein extract from E coli with ~50ng to 500ng of the antigen (tagged fusion protein)SecondaryRabbit anti-mouse IgG + IgM, (H+L) horseradish peroxidase conjugated, at 1/5000 dilution

Anti-CCKBR antibody - ab76250 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-CCKBR antibody (ab76250) at 1/500 dilutionLane 1 : Extracts from COS-7 cellsLane 2 : Extracts from A549 cellsLane 3 : Extracts from K562 cellsLane 4 : Extracts from K562 cells plus 5µg immunizing peptideLysates/proteins at 5 µg per lane.

Anti-CCKBR / Cckb Antibody (aa206-219) - LS-C89021 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CCKBR / Cckb Antibody (aa191-204) - LS-C128135 from LifeSpan Bioscience

Prices $680.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-CCKBR / Cckb Antibody (aa206-219) - LS-C121614 from LifeSpan Bioscience

Prices $455.00
Sizes 20 µl
Host Rabbit
Clonality Polyclonal

Anti-CCKBR / Cckb Antibody (aa191-204) - LS-C128133 from LifeSpan Bioscience

Prices $385.00
Sizes 20 µl
Host Rabbit
Clonality Polyclonal

Anti-CCKBR / Cckb Antibody (aa496-511) - LS-C193973 from LifeSpan Bioscience

Prices $905.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CCKBR / Cckb Antibody (aa11-60) - LS-C120565 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts from A549/COS7/K562 cells, using CCKBR Antibody. The lane on the right is treated with the synthesized peptide.

Anti-CCKBR / Cckb Antibody (aa277-326) - LS-C146467 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
CCKBR antibody LS-C146467 Western blot of Placenta lysate. Antibody concentration 1 ug/ml.

Anti-CCKBR / Cckb Antibody (Leu54) - LS-C177392 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of CCK-BR (L54) pAb in extracts from HeLa cells.

Anti-CCKBR / Cckb Antibody (aa251-266) IHC-plus™ - LS-B2325 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-CCKBR antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2325 concentration 5 ug/ml.

Anti-CCKBR / Cckb Antibody (Extracellular Domain) IHC-plus™ - LS-A6535 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-CCKBR / Cckb antibody IHC of human Colon, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-CCKBR / Cckb Antibody (Cytoplasmic Domain) IHC-plus™ - LS-A1282 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-CCKBR / Cckb antibody IHC of human Stomach, Adenocarcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Cholecystokinin-B R/CCKBR Antibody - NB100-2803 from Novus Biologicals

Prices $299.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Western Blot: Cholecystokinin-B R/CCKBR Antibody [NB100-2803] - (1ug/ml) staining of Mouse Pancreas lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Cholecystokinin-B R/CCKBR Antibody - NBP1-85837 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: CCKBR Antibody [NBP1-85837] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10<br/>Lane 2: Human cell line RT-4<br/>Lane 3: Human cell line U-251MG sp

Cholecystokinin-B R/CCKBR Antibody - NLS1282 from Novus Biologicals

Prices $329.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Cholecystokinin-B R/CCKBR Antibody - NLS6535 from Novus Biologicals

Prices $329.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: Cholecystokinin-B R/CCKBR Antibody [NLS6535] - Anti-CCKBR / Cckb antibody IHC of human Colon, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Gastrin receptor/CCKBR Antibody - bs-1777R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Formalin-fixed and paraffin embedded rat brain labeled with Anti-Gastrin receptor Polyclonal Antibody, Unconjugated (bs-1777R) at 1:200 followed by conjugation to the secondary antibody and DAB staining
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