CCKBR

Gene Symbol CCKBR
Entrez Gene 887
Alt Symbol CCK-B, CCK2R, GASR
Species Human
Gene Type protein-coding
Description cholecystokinin B receptor
Other Description CCK-B receptor|CCK-BR|CCK2 receptor|CCK2-R|cholecystokinin-2 receptor|gastrin receptor|gastrin/cholecystokinin type B receptor
Swissprots Q9UBV1 Q96LC6 Q9NYK7 O75824 P32239 Q16144 A8K7P9 Q92492
Accessions AAC37528 AAD14956 BAA04759 EAW68734 EAW68735 P32239 AF239668 AAF67174 AF441129 AAN32829 AK226020 AK292064 BAF84753 AK314266 AY029770 AAK38351 AY322551 AAP84364 BC000740 AAH00740 BT006789 AAP35435 CX762706 D13305 BAA02564 DA297178 DQ335648 ABC86718 DQ335649 ABC86719 DQ335650 ABC86720 DQ335651 ABC86721 DQ890577 ABM92194 DQ893737 ABM84663 L04473 AAA35660 L07746 AAA91831 L08112 AAA35657 S70057 AAB30766 S76072 AAB33740 Y13464 XM_005253210 XP_005253267 XM_011520443 XP_011518745 NM_176875 NP_795344
Function Receptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
Subcellular Location Cell membrane; Multi-pass membrane protein.
Tissue Specificity Isoform 1 is expressed in brain, pancreas, stomach, the colon cancer cell line LoVo and the T-lymphoblastoma Jurkat, but not in heart, placenta, liver, lung, skeletal muscle, kidney or the stomach cancer cell line AGS. Expressed at high levels in the small cell lung cancer cell line NCI-H510, at lower levels in NCI-H345, NCI-H69 and GLC-28 cell lines, not expressed in GLC-19 cell line. Within the stomach, expressed at high levels in the mucosa of the gastric fundus and at low levels in the antrum and duodenum. Isoform 2 is present in pancreatic cancer cells and colorectal cancer cells, but not in normal pancreas or colonic mucosa. Isoform 3 is expressed in brain, pancreas, stomach, the stomach cancer cell line AGS and the colon cancer cell line LoVo. {ECO:0000269|PubMed:10913157, ECO:0000269|PubMed:12429993, ECO:0000269|PubMed:7848914, ECO:0000269|PubMed:7887934, ECO:0000269|PubMed:8185170, ECO:0000269|PubMed:8349705}.
Top Pathways Calcium signaling pathway, Gastric acid secretion, Neuroactive ligand-receptor interaction

Human CCKBR / Cckb ELISA Kit (Sandwich ELISA) - LS-F4410 from LifeSpan Bioscience

Category ELISA Kit
Prices $690.00
Sizes 1 plate
Sensitivity 0.052 ng/ml
Range 0.156-10 ng/ml

Human CCKBR ELISA Kit - abx150976 from Abbexa

Category ELISA Kit
Sensitivity 0.052 ng/ml
Range 0.156 ng/ml - 10 ng/ml

Human Gastrin Receptor ELISA Kit - abx052504 from Abbexa

Category ELISA Kit

Cholecystokinin B Receptor, CCKBR, Human, ELISA Kit - E-EL-H0722 from ARP American Research Products

Category ELISA Kit
Prices $522.00
Sizes 96 t
Sensitivity 0.188
Range 0.313-20ng/mL

Cholecystokinin B Receptor (CCKBR), Human, ELISA Kit - SEB051Hu from ARP American Research Products

Category ELISA Kit
Prices $685.00
Sizes 96 t
Sensitivity 0.052ng/mL
Range 0.156-10ng/mL

Cholecystokinin B Receptor, Human, ELISA Kit - E01C0377 from ARP American Research Products

Category ELISA Kit
Prices $535.00, $735.00
Sizes 48 t, 96 t

Gastrin Receptor, GasR, Human, ELISA Kit - E-EL-H1148 from ARP American Research Products

Category ELISA Kit
Prices $522.00
Sizes 96 t

Gastrin receptor, GsaR, Human, ELISA Kit - CSB-E08993h from ARP American Research Products

Category ELISA Kit
Prices $550.00, $790.00, $791.00, $794.00
Sizes 48 t, 96 t, 5 x 96t, 10 x 96t
Sensitivity 5.8 pg/ml
Range 23.5 pg/ml-1500 pg/ml

Gastrin/cholecystokinin type B receptor, CCKBR, Human, ELISA Kit - E1051h from ARP American Research Products

Category ELISA Kit
Prices $596.00
Sizes 96 t

Cholecystokinin B Receptor, CCKBR, Mouse, ELISA Kit - E-EL-M0278 from ARP American Research Products

Category ELISA Kit
Prices $585.00
Sizes 96 t

Cholecystokinin B Receptor, CCKBR, Rabbit, ELISA Kit - E-EL-RB2008 from ARP American Research Products

Category ELISA Kit
Prices $648.00
Sizes 96 t

Gastrin Receptor, GasR, Rabbit, ELISA Kit - E-EL-RB0434 from ARP American Research Products

Category ELISA Kit
Prices $585.00
Sizes 96 t

Cholecystokinin B Receptor, CCKBR, Chicken, ELISA Kit - E-EL-Ch1913 from ARP American Research Products

Category ELISA Kit
Prices $522.00
Sizes 96 t

Gastrin Receptor, GasR, Chicken, ELISA Kit - E-EL-Ch0167 from ARP American Research Products

Category ELISA Kit
Prices $445.50
Sizes 96 t

Cholecystokinin B Receptor, CCKBR, Porcine, ELISA Kit - E-EL-P0036 from ARP American Research Products

Category ELISA Kit
Prices $585.00
Sizes 96 t

Gastrin Receptor, GasR, Porcine, ELISA Kit - E-EL-P1445 from ARP American Research Products

Category ELISA Kit
Prices $585.00
Sizes 96 t

Cholecystokinin B Receptor, CCKBR, Sheep, ELISA Kit - E-EL-S0517 from ARP American Research Products

Category ELISA Kit
Prices $648.00
Sizes 96 t

Gastrin Receptor, GasR, Sheep, ELISA Kit - E-EL-S0924 from ARP American Research Products

Category ELISA Kit
Prices $504.00
Sizes 96 t

Cholecystokinin B Receptor, CCKBR, Guinea Pig, ELISA Kit - E-EL-GP1186 from ARP American Research Products

Category ELISA Kit
Prices $522.00
Sizes 96 t

Cholecystokinin B Receptor, CCKBR, Monkey, ELISA Kit - E-EL-MK0789 from ARP American Research Products

Category ELISA Kit
Prices $585.00
Sizes 96 t

Gastrin Receptor, GasR, Monkey, ELISA Kit - E-EL-MK1639 from ARP American Research Products

Category ELISA Kit
Prices $585.00
Sizes 96 t

Human CCKBR ELISA Kit - HC0384 from NeoScientific

Category ELISA Kit
Prices $495.00
Sizes 96 t

Anserine CCKBR ELISA Kit - AC0384 from NeoScientific

Category ELISA Kit
Prices $495.00
Sizes 96 t

CCKBR, ELISA Kit - MBS2503461 from MyBioSource

Category ELISA Kit
Prices $490.00, $585.00, $2,475.00, $4,360.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.094ng/mL
Range 0.156-10ng/mL

CCKBR, ELISA Kit - MBS2504518 from MyBioSource

Category ELISA Kit
Prices $450.00, $535.00, $2,255.00, $3,975.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
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