| Gene Symbol |
VRK2
|
| Entrez Gene |
7444
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
vaccinia related kinase 2
|
| Other Description |
serine/threonine-protein kinase VRK2|vaccinia virus B1R-related kinase 2
|
| Swissprots |
Q86Y07 Q8IXI5 D6W5D4 Q86Y12 D6W5D6 Q86Y11 Q86Y09 Q53S39 Q53EU9 Q53S77 Q86Y08 Q53TU1 Q86Y10 B4DKL0 Q49AK9 Q99987
|
| Accessions |
AAX93262 AAY14648 AAY15019 EAX00062 EAX00063 EAX00064 EAX00065 EAX00066 EAX00067 EAX00068 Q86Y07 AB000450 BAA19109 AJ512204 CAD54446 AK058199 AK223540 BAD97260 AK292727 BAF85416 AK295193 BAH12007 AK296611 BAG59222 AK307113 AK311205 AY228367 AAO73047 AY228368 AAO73048 AY228369 AAO73049 AY228370 AAO73050 AY228371 AAO73051 AY228372 AAO73052 BC021663 AAH21663 BC027854 AAH27854 BC036434 BI906749 DA273734 DB227029 DQ890932 ABM81858 DQ894094 ABM85020 XM_005264540 XP_005264597 XM_005264541 XP_005264598 XM_006712090 XP_006712153 XM_006712091 XP_006712154 XM_006712092 XP_006712155 XM_006712093 XP_006712156 XM_011533092 XP_011531394 XM_011533093 XP_011531395 XM_011533094 XP_011531396 NM_001130480 NP_001123952 NM_001130481 NP_001123953 NM_001130482 NP_001123954 NM_001130483 NP_001123955 NM_001288836 NP_001275765 NM_001288837 NP_001275766 NM_001288838 NP_001275767 NM_001288839 NP_001275768 NM_006296 NP_006287
|
| Function |
Serine/threonine kinase that regulates several signal transduction pathways. Isoform 1 modulates the stress response to hypoxia and cytokines, such as interleukin-1 beta (IL1B) and this is dependent on its interaction with MAPK8IP1, which assembles mitogen-activated protein kinase (MAPK) complexes. Inhibition of signal transmission mediated by the assembly of MAPK8IP1-MAPK complexes reduces JNK phosphorylation and JUN-dependent transcription. Phosphorylates 'Thr-18' of p53/TP53, histone H3, and may also phosphorylate MAPK8IP1. Phosphorylates BANF1 and disrupts its ability to bind DNA and reduces its binding to LEM domain-containing proteins. Downregulates the transactivation of transcription induced by ERBB2, HRAS, BRAF, and MEK1. Blocks the phosphorylation of ERK in response to ERBB2 and HRAS. Can also phosphorylate the following substrates that are commonly used to establish in vitro kinase activity: casein, MBP and histone H2B, but it is not sure that this is physiologically relevan
|
| Subcellular Location |
Isoform 1: Cytoplasm. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass type IV membrane protein {ECO:0000305}. Mitochondrion membrane {ECO:0000305}; Single-pass type IV membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Isoform 1 and isoform 2 are expressed in various tumor cell lines. Expression of isoform 1 inversely correlates with ERBB2 in breast carcinomas (at protein level). Widely expressed. Highly expressed in fetal liver, skeletal muscle, pancreas, heart, peripheral blood leukocytes and testis. {ECO:0000269|PubMed:16704422, ECO:0000269|PubMed:20679487, ECO:0000269|PubMed:9344656}.
|
![Western Blot: VRK2 Overexpression Lysate (Adult Normal) [NBL1-17760] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for VRK2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/6356_VRK2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-17760-img0002.jpg)
![Western Blot: VRK2 Overexpression Lysate (Adult Normal) [NBP2-09513] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for VRK2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/10374_VRK2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-09513-img0001.jpg)