Nfkbia
| Gene Symbol | Nfkbia |
|---|---|
| Entrez Gene | 18035 |
| Alt Symbol | AI462015, Nfkbi |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha |
| Other Description | I(Kappa)B(alpha)|I-kappa-B-alpha|I-kappaBalpha|NF-kappa-B inhibitor alpha|ikB-alpha|ikappaBalpha|nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, alpha|nuclear factor of kappa light polyp gene enhancer in B-cell 1|nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha |
| Swissprots | Q9Z1E3 Q3UB40 Q3U9W9 Q80ZX5 |
| Accessions | AAD10341 EDL36726 Q9Z1E3 AI462015 AK089215 AK151115 BAE30124 AK151608 BAE30547 AK161622 BC046754 AAH46754 CF379853 U36277 AAA79696 NM_010907 NP_035037 |
| Function | Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription. {ECO:0000269|PubMed:10097128, ECO:0000269|PubMed:9990853}. |
| Subcellular Location | Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm by a nuclear localization signal (NLS) and a CRM1-dependent nuclear export. {ECO:0000250}. |
| Tissue Specificity | Highly expressed in lymph node, thymus followed by liver, brain, muscle, kidney, gastrointestinal and reproductive tract. |
| Top Pathways | Chronic myeloid leukemia, Epstein-Barr virus infection, Small cell lung cancer, B cell receptor signaling pathway, Adipocytokine signaling pathway |
NFKBIA/IKB alpha Polyclonal Antibody - bs-1287R from Bioss
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NFKBIA/IKB alpha Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-1287R-A350 from Bioss
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NFKBIA/IKB alpha Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-1287R-A488 from Bioss
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NFKBIA/IKB alpha Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-1287R-A555 from Bioss
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NFKBIA/IKB alpha Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-1287R-A647 from Bioss
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NFKBIA/IKB alpha Polyclonal Antibody, Cy3 Conjugated - bs-1287R-Cy3 from Bioss
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NFKBIA/IKB alpha Polyclonal Antibody, Cy5 Conjugated - bs-1287R-Cy5 from Bioss
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NFKBIA/IKB alpha Polyclonal Antibody, Cy5.5 Conjugated - bs-1287R-Cy5.5 from Bioss
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NFKBIA/IKB alpha Polyclonal Antibody, Cy7 Conjugated - bs-1287R-Cy7 from Bioss
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NFKBIA/IKB alpha Polyclonal Antibody, FITC Conjugated - bs-1287R-FITC from Bioss
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Rabbit Anti-NFKBIA/IKB alpha Polyclonal Antibody, PE Conjugated - bs-1287R-PE from Bioss
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NFKBIA/IKB alpha Polyclonal Antibody, Biotin Conjugated - bs-1287R-Biotin from Bioss
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NFKBIA/IKB alpha Polyclonal Antibody, HRP Conjugated - bs-1287R-HRP from Bioss
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IKB alpha antibody - GTX27217 from GeneTex
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NFKBIA Antibody (OABF00605) - OABF00605 from Aviva Systems Biology
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IKB alpha antibody - 70R-34217 from Fitzgerald
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IKBA antibody - 70R-31653 from Fitzgerald
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IKB alpha antibody (Tyr42) - 70R-34200 from Fitzgerald
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IkB alpha antibody (Tyr305) - 70R-35607 from Fitzgerald
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IKB alpha antibody (Ser32/Ser36) - 70R-37230 from Fitzgerald
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IkB alpha antibody - 70R-37560 from Fitzgerald
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IkB alpha antibody - 70R-11718 from Fitzgerald
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IKB alpha antibody - 70R-34201 from Fitzgerald
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IKB alpha antibody - 70R-35813 from Fitzgerald
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IKB alpha antibody (Tyr42) - 70R-37239 from Fitzgerald
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