Gene Symbol | Nfkbia |
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Entrez Gene | 18035 |
Alt Symbol | AI462015, Nfkbi |
Species | Mouse |
Gene Type | protein-coding |
Description | nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha |
Other Description | I(Kappa)B(alpha)|I-kappa-B-alpha|I-kappaBalpha|NF-kappa-B inhibitor alpha|ikB-alpha|ikappaBalpha|nuclear factor of kappa light chain gene enhancer in B-cells inhibitor, alpha|nuclear factor of kappa light polyp gene enhancer in B-cell 1|nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha |
Swissprots | Q9Z1E3 Q3UB40 Q3U9W9 Q80ZX5 |
Accessions | AAD10341 EDL36726 Q9Z1E3 AI462015 AK089215 AK151115 BAE30124 AK151608 BAE30547 AK161622 BC046754 AAH46754 CF379853 U36277 AAA79696 NM_010907 NP_035037 |
Function | Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals. On cellular stimulation by immune and proinflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription. {ECO:0000269|PubMed:10097128, ECO:0000269|PubMed:9990853}. |
Subcellular Location | Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm by a nuclear localization signal (NLS) and a CRM1-dependent nuclear export. {ECO:0000250}. |
Tissue Specificity | Highly expressed in lymph node, thymus followed by liver, brain, muscle, kidney, gastrointestinal and reproductive tract. |
Top Pathways | Chronic myeloid leukemia, Epstein-Barr virus infection, Small cell lung cancer, B cell receptor signaling pathway, Adipocytokine signaling pathway |
Inhibitory Subunit Of NF Kappa B Alpha (IkBa), Mouse, ELISA Kit - SEB848Mu from ARP American Research Products
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NF-kappa-B inhibitor alpha (NFKBIA), Mouse, ELISA Kit - CSB-EL015761MO from ARP American Research Products
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NF-kappa-B inhibitor alpha (NFKBIA), Mouse, ELISA Kit - E03N0546 from ARP American Research Products
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NF-kappa-B inhibitor alpha, Nfkbia, Mouse, ELISA Kit - E1848m from ARP American Research Products
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NF-kappa-B Inhibitor Alpha, ELISA Kit - MBS087160 from MyBioSource
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Mouse NF-kappa-B inhibitor alpha(NFKBIA) ELISA kit - CSB-EL015761MO from Cusabio
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ELISA Kit for Inhibitory Subunit Of NF Kappa B Alpha (IkBa) - SEB848Mu from Cloud-clone
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nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha, ELISA Kit - MBS900496 from MyBioSource
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Mouse IKappaBAlpha(Inhibitory Subunit of NF Kappa B Alpha) ELISA Kit - E-EL-M0863 from Iwai North America Inc.
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Inhibitory Subunit of NF Kappa B Alpha, IkBa, Mouse, ELISA Kit - E-EL-M0863 from ARP American Research Products
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Mouse NF-kappa-B inhibitor alpha (NFKBIA) ELISA Kit - EKC37494 from Biomatik
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Mouse IkappaBalpha ELISA Kit - E056644 from Biobool
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Mouse Nfkbia ELISA Kit - E061584 from Biobool
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NFKBIA ELISA Kit (Mouse) (OKEH06432) - OKEH06432 from Aviva Systems Biology
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Inhibitory Subunit Of NF Kappa B Alpha (IkBa), ELISA Kit - MBS455123 from MyBioSource
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NF-kappa-B inhibitor alpha, ELISA Kit - MBS289742 from MyBioSource
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