MTHFD1L

Gene Symbol	MTHFD1L
Entrez Gene	25902
Alt Symbol	FTHFSDC1, MTC1THFS, dJ292B18.2
Species	Human
Gene Type	protein-coding
Description	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like
Other Description	10-formyl-THF synthetase|formyltetrahydrofolate synthetase domain containing 1|monofunctional C1-tetrahydrofolate synthase, mitochondrial
Swissprots	Q2TBF3 Q8WVW0 Q9H789 Q9UFU8 Q96HG8 Q6UB35
Accessions	CAM36319 CAM36320 CBF65969 CBF74049 CBU90841 CBU96477 EAW47760 EAW47761 EAW47762 EAW47763 Q6UB35 AA478842 AB127387 BAD93193 AK024798 BAB15009 AK127089 AK310342 AK315378 BAG37771 AL117452 CAB55934 AV704883 AW593866 AY374130 AAQ82696 AY374131 AAQ82697 BC008629 AAH08629 BC017477 AAH17477 BC110319 AAI10320 BC136685 AAI36686 BC144368 AAI44369 BC144369 BE735249 BQ062382 DA195967 DB727926 XM_005266907 XP_005266964 XM_005266910 XP_005266967 XM_005266911 XP_005266968 XM_011535729 XP_011534031 XM_011535730 XP_011534032 XM_011535731 XP_011534033 XM_011535732 XP_011534034 XM_011535733 XP_011534035 XM_011535734 XP_011534036 XM_011535735 XP_011534037 XM_011535736 XP_011534038 XM_011535737 XP_011534039 XM_011535738 XP_011534040 NM_001242767 NP_001229696 NM_001242768 NP_001229697 NM_001242769 NP_001229698 NM_015440 NP_056255
Function	May provide the missing metabolic reaction required to link the mitochondria and the cytoplasm in the mammalian model of one-carbon folate metabolism in embryonic an transformed cells complementing thus the enzymatic activities of MTHFD2. {ECO:0000250}.
Subcellular Location	Mitochondrion {ECO:0000269|PubMed:12937168}.
Tissue Specificity	Detected in most tissues, highest expression found in placenta, thymus and brain. Low expression is found in liver and skeletal muscle. Up-regulated in colon adenocarcinoma. {ECO:0000269|PubMed:12937168, ECO:0000269|PubMed:15013446}.
Top Pathways	One carbon pool by folate

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human MTHFD1L full length protein - ab161832 from Abcam Category Protein Source Wheat germ Species Human

Human MTHFD1L protein fragment - ab161833 from Abcam Category Protein Source Wheat germ Species Human

FTHFSDC1 / MTHFD1L Antibody Blocking Peptide - LS-E27680 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human MTHFD1L Protein - H00025902-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human MTHFD1L Protein - H00025902-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

MTHFD1L Peptide - AC21-2496-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

MTHFD1L - H00025902-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

MTHFD1L - H00025902-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

MTHFD1L - H00025902-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

MTHFD1L - H00025902-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

MTHFD1L Peptide - 42-396P from ProSci Category Peptide Species Human, Mouse, Rat

MTHFD1L fusion protein - Ag9036 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

MTHFD1L fusion protein - Ag9061 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human MTHFD1L, His-tagged - MTHFD1L-1082H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Monofunctional C1-tetrahydrofolate synthase, mitochondrial(MTHFD1L) ,partial - CSB-YP754385HU CSB-EP754385HU CSB-BP754385HU CSB-MP754385HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

MTHFD1L Protein - abx164584 from Abbexa Category Protein Species Human, Mouse, Rat

MTHFD1L, Peptide - MBS427649 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Rat, Dog, Pig, Bovine

MTHFD1L Recombinant Protein Antigen - NBP2-37864PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

MTHFD1L Recombinant Protein Antigen - NBP2-37863PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

MTHFD1L Peptide, Human - M34GP09878H from Creative Peptides Category Peptide Source Synthetic. Species Human

MTHFD1L Immunizing peptide - orb66216 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg

MTHFD1L Recombinant Protein Antigen - NBP2-46781PEP from Novus Biologicals Category Protein Prices $229.00 Sizes 100 µl Source E.coli Species Human

Monofunctional C1-tetrahydrofolate synthase, mitochondrial (MTHFD1L), partial, Recombinant Protein - MBS1363309 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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