Gene Symbol | MFSD8 |
---|---|
Entrez Gene | 256471 |
Alt Symbol | CCMD, CLN7 |
Species | Human |
Gene Type | protein-coding |
Description | major facilitator superfamily domain containing 8 |
Other Description | ceroid-lipofuscinosis, neuronal 7, late infantile|major facilitator superfamily domain-containing protein 8 |
Swissprots | Q8NHS3 Q8N2P3 B7Z205 B2RDM1 |
Accessions | EAX05193 EAX05194 EAX05195 Q8NHS3 AA242881 AK074564 BAC11062 AK294184 BAH11691 AK294439 BAH11766 AK294527 BAH11798 AK294957 BAH11934 AK315596 BAG37968 BC029503 AAH29503 BI553701 BQ015234 CB956202 CN310788 CX873070 DA481070 JF432263 ADZ15480 XM_005262893 XP_005262950 XM_005262896 XP_005262953 XM_005262897 XP_005262954 XM_005262898 XP_005262955 XM_005262900 XP_005262957 XM_011531830 XP_011530132 XM_011531831 XP_011530133 XM_011531832 XP_011530134 XR_938717 NM_152778 NP_689991 |
Function | May be a carrier that transport small solutes by using chemiosmotic ion gradients. {ECO:0000305}. |
Subcellular Location | Lysosome membrane {ECO:0000269|PubMed:17564970, ECO:0000269|PubMed:17897319, ECO:0000269|PubMed:20406422}; Multi-pass membrane protein {ECO:0000269|PubMed:17564970, ECO:0000269|PubMed:17897319, ECO:0000269|PubMed:20406422}. Note=Sorting to lysosomes involves tyrosine- and/or dileucine-based motifs. |
Tissue Specificity | Expressed at very low levels in all tissues tested. {ECO:0000269|PubMed:17564970}. |
Top Pathways | Lysosome |
MFSD8 CRISPR/Cas9 KO Plasmid (h) - sc-415239 from Santa Cruz Biotechnology
|
||||||||
MFSD8 HDR Plasmid (h) - sc-415239-HDR from Santa Cruz Biotechnology
|
||||||||
MFSD8 Double Nickase Plasmid (h) - sc-415239-NIC from Santa Cruz Biotechnology
|
||||||||
MFSD8 Double Nickase Plasmid (h2) - sc-415239-NIC-2 from Santa Cruz Biotechnology
|
||||||||
MFSD8 CRISPR Activation Plasmid (h) - sc-415239-ACT from Santa Cruz Biotechnology
|
||||||||
MFSD8 CRISPR Activation Plasmid (h2) - sc-415239-ACT-2 from Santa Cruz Biotechnology
|
||||||||
MFSD8 Lentiviral Activation Particles (h) - sc-415239-LAC from Santa Cruz Biotechnology
|
||||||||
MFSD8 Lentiviral Activation Particles (h2) - sc-415239-LAC-2 from Santa Cruz Biotechnology
|
||||||||
MFSD8 siRNA (h) - sc-89155 from Santa Cruz Biotechnology
|
||||||||
MFSD8 shRNA Plasmid (h) - sc-89155-SH from Santa Cruz Biotechnology
|
||||||||
MFSD8 shRNA (h) Lentiviral Particles - sc-89155-V from Santa Cruz Biotechnology
|
||||||||
MISSION® esiRNA - EHU057611 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN2545 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2545 from Sigma-Aldrich
|
||||||||
MFSD8 siRNA (Human) - CRJ6759 from Cohesion Biosciences
|
||||||||
shRNA set against Human MFSD8 (NM_152778.2) - SHH341291 from Creative biogene
|
||||||||
MFSD8 shRNA Plasmid (Human) - CHJ6759 from Cohesion Biosciences
|
||||||||
MFSD8 miRNA 3'UTR clone - MiUTR4H-TG05502 from Creative biogene
|
||||||||