| Gene Symbol | KATNA1 |
|---|---|
| Entrez Gene | 11104 |
| Alt Symbol | - |
| Species | Human |
| Gene Type | protein-coding |
| Description | katanin p60 (ATPase containing) subunit A 1 |
| Other Description | katanin p60 (ATPase-containing) subunit A 1|katanin p60 ATPase-containing subunit A1|katanin p60 subunit A1|p60 katanin |
| Swissprots | E1P5A3 Q86VN2 O75449 Q5TFA9 Q9NU52 Q5TFA8 |
| Accessions | EAW47793 EAW47794 EAW47795 O75449 AF056022 AAC25114 AK292090 BAF84779 BC050428 AAH50428 CA426364 DB031858 XM_005266804 XP_005266861 XM_005266805 XP_005266862 XM_011535397 XP_011533699 NM_001204076 NP_001191005 NM_007044 NP_008975 |
| Function | Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth. {ECO:0000255|HAMAP-Rule:MF_03023}. |
| Subcellular Location | Cytoplasm. Midbody. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000255|HAMAP- Rule:MF_03023}. Cytoplasm, cytoskeleton, spindle pole. Note=Predominantly cytoplasmic. Localized diffusely in the cytoplasm during the interphase. During metaphase is localized throughout the cell and more widely dispersed than the microtubules. In anaphase and telophase is localized at the midbody region. Also localized to the interphase centrosome and the mitotic spindle poles. Enhanced recruitment to the mitotic spindle poles requires microtubules and interaction with KATNB1. |