Gene Symbol | TMOD4 |
---|---|
Entrez Gene | 29765 |
Alt Symbol | SK-TMOD |
Species | Human |
Gene Type | protein-coding |
Description | tropomodulin 4 (muscle) |
Other Description | actin-capping protein|skeletal muscle tropomodulin|tropomodulin-4 |
Swissprots | B7Z6N9 Q9NZQ9 Q5JR83 Q8WVL3 Q9UKH2 |
Accessions | AAK06765 AAM73676 EAW53463 EAW53464 EAW53465 Q9NZQ9 AF165217 AAF01277 AF177173 AAF31672 AK092700 BAC03951 AK300675 BAH13325 AK313280 BAG36088 BC017810 AAH17810 BX647346 DC385872 HQ447602 ADQ32088 XM_005245104 XP_005245161 XM_011509449 XP_011507751 NM_013353 NP_037485 |
Function | Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton. |
Subcellular Location | Cytoplasm, cytoskeleton. Note=In myofibrils with sarcomeric structure, localizes to the pointed end of actin thin filaments (PubMed:25250574). {ECO:0000269|PubMed:25250574}. |
Tissue Specificity | Highly expressed in skeletal muscle. {ECO:0000269|PubMed:10662549}. |