Gene Symbol | TMOD4 |
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Entrez Gene | 29765 |
Alt Symbol | SK-TMOD |
Species | Human |
Gene Type | protein-coding |
Description | tropomodulin 4 (muscle) |
Other Description | actin-capping protein|skeletal muscle tropomodulin|tropomodulin-4 |
Swissprots | B7Z6N9 Q9NZQ9 Q5JR83 Q8WVL3 Q9UKH2 |
Accessions | AAK06765 AAM73676 EAW53463 EAW53464 EAW53465 Q9NZQ9 AF165217 AAF01277 AF177173 AAF31672 AK092700 BAC03951 AK300675 BAH13325 AK313280 BAG36088 BC017810 AAH17810 BX647346 DC385872 HQ447602 ADQ32088 XM_005245104 XP_005245161 XM_011509449 XP_011507751 NM_013353 NP_037485 |
Function | Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton. |
Subcellular Location | Cytoplasm, cytoskeleton. Note=In myofibrils with sarcomeric structure, localizes to the pointed end of actin thin filaments (PubMed:25250574). {ECO:0000269|PubMed:25250574}. |
Tissue Specificity | Highly expressed in skeletal muscle. {ECO:0000269|PubMed:10662549}. |
tropomodulin 4 CRISPR/Cas9 KO Plasmid (h) - sc-407787 from Santa Cruz Biotechnology
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tropomodulin 4 HDR Plasmid (h) - sc-407787-HDR from Santa Cruz Biotechnology
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tropomodulin 4 Double Nickase Plasmid (h) - sc-407787-NIC from Santa Cruz Biotechnology
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tropomodulin 4 Double Nickase Plasmid (h2) - sc-407787-NIC-2 from Santa Cruz Biotechnology
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tropomodulin 4 CRISPR Activation Plasmid (h) - sc-407787-ACT from Santa Cruz Biotechnology
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tropomodulin 4 CRISPR Activation Plasmid (h2) - sc-407787-ACT-2 from Santa Cruz Biotechnology
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tropomodulin 4 Lentiviral Activation Particles (h) - sc-407787-LAC from Santa Cruz Biotechnology
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tropomodulin 4 Lentiviral Activation Particles (h2) - sc-407787-LAC-2 from Santa Cruz Biotechnology
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tropomodulin 4 siRNA (h) - sc-43468 from Santa Cruz Biotechnology
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tropomodulin 4 shRNA Plasmid (h) - sc-43468-SH from Santa Cruz Biotechnology
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tropomodulin 4 shRNA (h) Lentiviral Particles - sc-43468-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU037871 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN21699 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21699 from Sigma-Aldrich
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TMOD4 siRNA (Human) - CRH9220 from Cohesion Biosciences
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TMOD4 - MBS8206580 from MyBioSource
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shRNA set against Human TMOD4 (NM_013353.2) - SHH431344 from Creative biogene
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shRNA set against Human TMOD4(NM_013353.2) - SHL082136 from Creative biogene
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TMOD4 shRNA Plasmid (Human) - CHH9220 from Cohesion Biosciences
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TMOD4 miRNA 3'UTR clone - MiUTR1H-10572 from Creative biogene
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