ARFGAP1
| Gene Symbol | ARFGAP1 |
|---|---|
| Entrez Gene | 55738 |
| Alt Symbol | ARF1GAP, HRIHFB2281 |
| Species | Human |
| Gene Type | protein-coding |
| Description | ADP-ribosylation factor GTPase activating protein 1 |
| Other Description | ADP-ribosylation factor GTPase-activating protein 1|ARF1-directed GTPase-activating protein |
| Swissprots | Q9UIL0 E7EV62 B7Z3U0 B7Z8H8 B7ZBI3 E1P5I9 Q9NSU3 Q6PK71 Q96KC4 Q8N6T3 Q96T02 Q9NVF6 |
| Accessions | EAW75290 EAW75291 EAW75292 EAW75293 EAW75294 EAW75295 EAW75296 Q8N6T3 AA565406 AB015340 BAA88117 AK001629 BAA91796 AK027268 BAB55009 AK027441 BAB55113 AK095048 AK123367 AK123873 AK223427 BAD97147 AK296351 BAH12326 AK303454 BAH13964 AK308161 AL137744 CAB70901 AY927573 BC000786 AAH00786 BC006085 AAH06085 BC011876 AAH11876 BC028233 AAH28233 BC127893 BQ717837 DC300118 DC404137 HQ447319 ADQ31806 XM_006723823 XP_006723886 XM_011528901 XP_011527203 XM_011528902 XP_011527204 XR_936567 XR_936568 XR_936569 XR_936570 XR_936571 XR_936572 XR_936574 XR_936575 XR_936576 NM_001281482 NP_001268411 NM_001281483 NP_001268412 NM_001281484 NP_001268413 NM_018209 NP_060679 NM_175609 NP_783202 NR_104022 NR_104023 |
| Function | GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicle's fusion with target compartment. Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2. Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, as when ARF1 is deactivated. Its activity is stimulated by phosphoinosides and inhibited by phosphatidylcholine (By similarity). {ECO:0000250}. |
| Subcellular Location | Cytoplasm {ECO:0000250}. Golgi apparatus {ECO:0000250}. Note=Associates with the Golgi complex. {ECO:0000250}. |
| Top Pathways | Endocytosis |
ARFGAP1 CRISPR/Cas9 KO Plasmid (h) - sc-403939 from Santa Cruz Biotechnology
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ARFGAP1 HDR Plasmid (h) - sc-403939-HDR from Santa Cruz Biotechnology
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ARFGAP1 Double Nickase Plasmid (h) - sc-403939-NIC from Santa Cruz Biotechnology
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ARFGAP1 Double Nickase Plasmid (h2) - sc-403939-NIC-2 from Santa Cruz Biotechnology
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ARFGAP1 CRISPR Activation Plasmid (h) - sc-403939-ACT from Santa Cruz Biotechnology
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ARFGAP1 CRISPR Activation Plasmid (h2) - sc-403939-ACT-2 from Santa Cruz Biotechnology
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ARFGAP1 Lentiviral Activation Particles (h) - sc-403939-LAC from Santa Cruz Biotechnology
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ARFGAP1 Lentiviral Activation Particles (h2) - sc-403939-LAC-2 from Santa Cruz Biotechnology
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ARFGAP1 siRNA (h) - sc-72529 from Santa Cruz Biotechnology
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ARFGAP1 shRNA Plasmid (h) - sc-72529-SH from Santa Cruz Biotechnology
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ARFGAP1 shRNA (h) Lentiviral Particles - sc-72529-V from Santa Cruz Biotechnology
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ARFGAP1 RNAi - H00055738-R02 from Novus Biologicals
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ARFGAP1 RNAi - H00055738-R01 from Novus Biologicals
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MISSION® esiRNA - EHU075611 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3392 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3392 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR10715 from Sigma-Aldrich
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ARFGAP1 siRNA (Human) - CRJ0876 from Cohesion Biosciences
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ARFGAP1 - MBS8225298 from MyBioSource
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shRNA set against Human ARFGAP1 (NM_175609.1) - SHH239146 from Creative biogene
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shRNA set against Human ARFGAP1(NM_018209.2) - SHG068527 from Creative biogene
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shRNA set against Human ARFGAP1(NM_175609.1) - SHG068545 from Creative biogene
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Human ARFGAP1 siRNA - orb271377 from Biorbyt
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ARFGAP1 shRNA Plasmid (Human) - CHJ0876 from Cohesion Biosciences
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ARFGAP1 miRNA 3'UTR clone - MiUTR1H-00509 from Creative biogene
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