JPH1

Gene Symbol JPH1
Entrez Gene 56704
Alt Symbol JP-1, JP1
Species Human
Gene Type protein-coding
Description junctophilin 1
Other Description junctophilin type 1|junctophilin type1|junctophilin-1|mitsugumin72
Swissprots B2RTZ0 Q9HDC5
Accessions BAB11986 EAW87026 EAW87027 EAW87028 EAW87029 EAW87030 EAW87031 Q9HDC5 BC017980 BC049372 AAH49372 BC098299 AAH98299 BC098314 BC099736 BC113856 AAI13857 BC114464 AAI14465 BC139832 AAI39833 BC140875 AAI40876 BC140876 AAI40877 BX537756 CAD97825 CN272069 CR627477 CAH10677 XM_005251273 XP_005251330 XM_005251274 XP_005251331 XM_005251275 XP_005251332 NM_020647 NP_065698
Function Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH1 contributes to the construction of the skeletal muscle triad by linking the t-tubule (transverse-tubule) and SR (sarcoplasmic reticulum) membranes.
Subcellular Location Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Sarcoplasmic reticulum membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Note=Localized predominantly on the plasma membrane. The transmembrane domain is anchored in endoplasmic/sarcoplasmic reticulum membrane, while the N-terminal part associates with the plasma membrane. In skeletal muscle cells, it is predominantly localized at the junction of the A and I bands (By similarity). {ECO:0000250}.
Tissue Specificity Abundantly expressed in skeletal muscle. Very low levels in heart. {ECO:0000269|PubMed:10891348}.

Junctophilin-1 (N-15) - sc-51308 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Junctophilin-1 (N-15): sc-51308. Western blot analysis of Junctophilin-1 expression in C2C12 (A) and Sol8 (B) whole cell lysates.

Anti-JPH1 antibody - ab195312 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Whole cell lysate (0.5 or 1.0 mg per IP reaction; 20% of IP loaded) from 293T cells prepared using RIPA lysis buffer.  Antibodies: ab195312 used for IP at 6 µg per reaction. For blotting immunoprecipitated Junctophilin 1, ab195312 was used at 1 µg/mL.

Anti-JPH1 antibody - ab79062 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Lane 1 : Anti-JPH1 antibody (ab79062) at 1 µg/mlLane 2 : Anti-JPH1 antibody (ab79062) at 2 µg/mlLane 1 : 293 cell lysateLane 2 : 293 cell lysateLysates/proteins at 15 µg per lane.

Anti-JPH1 antibody - ab57425 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab57425 JPH1 antibody at 1ug/ml.

Anti-JPH1 Antibody (aa501-580) - LS-C308562 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-JPH1 Antibody (C-Terminus) - LS-C81400 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Lane A: Marker. Lane B: Jurkat cell lysate. Antibody concentration: 5.0 ug/ml. Gel concentration: 12%.

Anti-JPH1 Antibody (aa542-591) - LS-C81399 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Hela cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.

Anti-JPH1 Antibody (C-Terminus) - LS-C82882 from LifeSpan Bioscience

Prices $345.00, $1,035.00
Sizes 100 µg, 500 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of JPH1 in mouse skeletal muscle tissue with JPH1 antibody at 2.5 ug/ml.

JPH1 Antibody - NBP1-83075 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: JPH1 Antibody [NBP1-83075] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11<br/>Lane 2: Human cell line RT-4<br/>Lane 3: Human cell line U-251MG sp<br/>Lane 4: Human plasma (IgG/HSA depleted)<br/>Lane 5: Human liver tissue<br/>Lane 6: Human tonsil tissue

JPH1 Antibody - NBP1-83076 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: JPH1 Antibody [NBP1-83076] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11. Lane 2: Human cell line RT-4. Lane 3: Human cell line U-251MG sp. Lane 4: Human plasma (IgG/HSA depleted). Lane 5: Human liver tissue. Lane 6: Human tonsil tissue

JPH1 Antibody - NBP1-77338 from Novus Biologicals

Prices $329.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: JPH1 Antibody [NBP1-77338] - 293 cell lysate with JPH1 antibody at (A) 1 and (B) 2 ug/ml.

JPH1 Antibody (2E6) - H00056704-M04 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2E6

JPH1 Antibody - H00056704-A01 from Novus Biologicals

Host Mouse
Clonality Polyclonal

Anti-JPH1 antibody produced in rabbit - SAB3500328 from Sigma-Aldrich

Prices $348.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-JPH1: <B>Cat. No. SAB3500328</B>: Immunohistochemistry of JPH1 in mouse skeletal muscle tissue with JPH1 antibody at 2.5 μg/mL.

Anti-JPH1 antibody produced in rabbit - HPA009413 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-JPH1: <B>Cat. No. HPA009413</B>: Immunoperoxidase staining of formalin-fixed, paraffin-embedded human skeletal muscle tissue showing strong cytoplasmic staining of myocytes.

Anti-JPH1 antibody produced in rabbit - HPA008996 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-JPH1: <B>Cat. No. HPA008996</B>: Immunoperoxidase staining of formalin-fixed, paraffin-embedded human skeletal muscle shows strong cytoplasmic positivity in myocytes.

Anti-JPH1 (AB2) antibody produced in rabbit - AV49533 from Sigma-Aldrich

Prices $267.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Cell Type: Jurkat (<B>Cat. No. AV49533</B>).<BR/><B>Lanes</B><BR/>1. Antibody dilution (concentration) 5.0 μg/mL in cell type Jurkat

Anti-JPH1 (AB1) antibody produced in rabbit - AV49532 from Sigma-Aldrich

Prices $347.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Cell Type: HeLa (<B>Cat. No. AV49532</B>).<BR/><B>Lanes</B><BR/>1. Antibody dilution (concentration) 1 μg/mL in cell type HeLa

Monoclonal Anti-JPH1 antibody produced in mouse - WH0056704M4 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2E6
<B>Immunoblotting</B><BR/>Monoclonal Anti-JPH1, <B>Cat. No. WH0056704M4</B> used at the antibody concentration: 1 μg/mL. Specific band of ~34.8 kDa using immunogen protein lysate.

JPH1 antibody - C-terminal region (ARP49532_P050) - ARP49532_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

JPH1 antibody - C-terminal region (ARP49533_T100) - ARP49533_T100 from Aviva Systems Biology

Prices $229.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

JPH1-Antibody-monoclonal-M04 - AT2584a from Abgent, a WuXi AppTec company

Prices $315.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2E7
Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (34.43 KDa) .

JPH1 antibody, C-term - GTX46049 from GeneTex

Prices $319.00
Sizes 100 μg
Host Rabbit
Clonality Polyclonal

JPH1 antibody, C-term - GTX46050 from GeneTex

Prices $319.00
Sizes 50 μg
Host Rabbit
Clonality Polyclonal

JPH1 antibody - orb75099 from Biorbyt

Prices $723.00
Sizes 100 μg
Host Rabbit
Clonality Polyclonal
Western blot analysis of 293 cell lysate at (A) 1 and (B) 2 ug/mL using JPH1 antibody
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