JPH1

Gene Symbol JPH1
Entrez Gene 56704
Alt Symbol JP-1, JP1
Species Human
Gene Type protein-coding
Description junctophilin 1
Other Description junctophilin type 1|junctophilin type1|junctophilin-1|mitsugumin72
Swissprots B2RTZ0 Q9HDC5
Accessions BAB11986 EAW87026 EAW87027 EAW87028 EAW87029 EAW87030 EAW87031 Q9HDC5 BC017980 BC049372 AAH49372 BC098299 AAH98299 BC098314 BC099736 BC113856 AAI13857 BC114464 AAI14465 BC139832 AAI39833 BC140875 AAI40876 BC140876 AAI40877 BX537756 CAD97825 CN272069 CR627477 CAH10677 XM_005251273 XP_005251330 XM_005251274 XP_005251331 XM_005251275 XP_005251332 NM_020647 NP_065698
Function Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH1 contributes to the construction of the skeletal muscle triad by linking the t-tubule (transverse-tubule) and SR (sarcoplasmic reticulum) membranes.
Subcellular Location Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Sarcoplasmic reticulum membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}. Note=Localized predominantly on the plasma membrane. The transmembrane domain is anchored in endoplasmic/sarcoplasmic reticulum membrane, while the N-terminal part associates with the plasma membrane. In skeletal muscle cells, it is predominantly localized at the junction of the A and I bands (By similarity). {ECO:0000250}.
Tissue Specificity Abundantly expressed in skeletal muscle. Very low levels in heart. {ECO:0000269|PubMed:10891348}.

Junctophilin-1 CRISPR/Cas9 KO Plasmid (h) - sc-406177 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Junctophilin-1 HDR Plasmid (h) - sc-406177-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Junctophilin-1 Double Nickase Plasmid (h) - sc-406177-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Junctophilin-1 Double Nickase Plasmid (h2) - sc-406177-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Junctophilin-1 CRISPR Activation Plasmid (h) - sc-406177-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Junctophilin-1 CRISPR Activation Plasmid (h2) - sc-406177-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Junctophilin-1 Lentiviral Activation Particles (h) - sc-406177-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Junctophilin-1 Lentiviral Activation Particles (h2) - sc-406177-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Junctophilin-1 siRNA (h) - sc-72005 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Junctophilin-1 shRNA Plasmid (h) - sc-72005-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Junctophilin-1 shRNA (h) Lentiviral Particles - sc-72005-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

JPH1 RNAi - H00056704-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU078801 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN10876 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR11235 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr11235

JPH1 siRNA (Human) - CRJ1176 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

JPH1, siRNA - MBS828655 from MyBioSource

Category siRNA
Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human Jph1 (NM_020647.2) - SHH322167 from Creative biogene

Category siRNA
Species Reactivities Human

Human JPH1 siRNA - orb271677 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

JPH1 shRNA Plasmid (Human) - CHJ1176 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

JPH1 miRNA 3'UTR clone - MiUTR1H-05073 from Creative biogene

Species Reactivities Human
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