| Gene Symbol |
BUB1
|
| Entrez Gene |
699
|
| Alt Symbol |
BUB1A, BUB1L, hBUB1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
BUB1 mitotic checkpoint serine/threonine kinase
|
| Other Description |
BUB1 budding uninhibited by benzimidazoles 1 homolog|budding uninhibited by benzimidazoles 1 homolog|mitotic checkpoint serine/threonine-protein kinase BUB1|mitotic spindle checkpoint kinase|putative serine/threonine-protein kinase
|
| Swissprots |
F5GXI5 O43643 E9PC26 O43683 Q53QE4 O60626 O43430
|
| Accessions |
AAD43675 AAK29549 AAY14706 CBJ05771 CBJ21223 EAW50355 O43683 AF011387 AAC39546 AF043294 AAB97855 AF046078 AAC12729 AF047471 AAC03122 AF053305 AAC06259 AI635394 AK023540 AK225317 AK291221 BAF83910 AK302418 BAG63724 BC017038 AAH17038 BC028201 AAH28201 BP313176 DB453210 JF432720 ADZ15937 XR_923001 NM_001278616 NP_001265545 NM_001278617 NP_001265546 NM_004336 NP_004327
|
| Function |
Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Plays an important role in defining SGOL1 localization and thereby affects sister chromatid cohesion. Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activat
|
| Subcellular Location |
Nucleus. Chromosome, centromere, kinetochore. Note=Nuclear in interphase cells. Accumulates gradually during G1 and S phase of the cell cycle, peaks at G2/M, and drops dramatically after mitosis. Localizes to the outer kinetochore. Kinetochore localization is required for normal mitotic timing and checkpoint response to spindle damage and occurs very early in prophase. AURKB, CASC5 and INCENP are required for kinetochore localization (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
High expression in testis and thymus, less in colon, spleen, lung and small intestine. Expressed in fetal thymus, bone marrow, heart, liver, spleen and thymus. Expression is associated with cells/tissues with a high mitotic index.
|
| Top Pathways |
Cell cycle, Progesterone-mediated oocyte maturation, Oocyte meiosis
|