BUB1

Gene Symbol	BUB1
Entrez Gene	699
Alt Symbol	BUB1A, BUB1L, hBUB1
Species	Human
Gene Type	protein-coding
Description	BUB1 mitotic checkpoint serine/threonine kinase
Other Description	BUB1 budding uninhibited by benzimidazoles 1 homolog|budding uninhibited by benzimidazoles 1 homolog|mitotic checkpoint serine/threonine-protein kinase BUB1|mitotic spindle checkpoint kinase|putative serine/threonine-protein kinase
Swissprots	F5GXI5 O43643 E9PC26 O43683 Q53QE4 O60626 O43430
Accessions	AAD43675 AAK29549 AAY14706 CBJ05771 CBJ21223 EAW50355 O43683 AF011387 AAC39546 AF043294 AAB97855 AF046078 AAC12729 AF047471 AAC03122 AF053305 AAC06259 AI635394 AK023540 AK225317 AK291221 BAF83910 AK302418 BAG63724 BC017038 AAH17038 BC028201 AAH28201 BP313176 DB453210 JF432720 ADZ15937 XR_923001 NM_001278616 NP_001265545 NM_001278617 NP_001265546 NM_004336 NP_004327
Function	Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Plays an important role in defining SGOL1 localization and thereby affects sister chromatid cohesion. Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activat
Subcellular Location	Nucleus. Chromosome, centromere, kinetochore. Note=Nuclear in interphase cells. Accumulates gradually during G1 and S phase of the cell cycle, peaks at G2/M, and drops dramatically after mitosis. Localizes to the outer kinetochore. Kinetochore localization is required for normal mitotic timing and checkpoint response to spindle damage and occurs very early in prophase. AURKB, CASC5 and INCENP are required for kinetochore localization (By similarity). {ECO:0000250}.
Tissue Specificity	High expression in testis and thymus, less in colon, spleen, lung and small intestine. Expressed in fetal thymus, bone marrow, heart, liver, spleen and thymus. Expression is associated with cells/tissues with a high mitotic index.
Top Pathways	Cell cycle, Progesterone-mediated oocyte maturation, Oocyte meiosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Bub1 protein (Tagged) - ab127642 from Abcam Category Protein Prices $235.00 Sizes 20 µg Source Baculovirus infected sf9 cells Species Human

Human Bub1 full length protein - ab131779 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

Human Bub1 peptide - ab98253 from Abcam Category Peptide Prices $176.00 Sizes 100 µg

Human Bub1 protein fragment - ab152247 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

BUB1 Antibody Blocking Peptide - LS-E7835 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

BUB1 Antibody Blocking Peptide - LS-E30351 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

BUB1 Blocking Peptide - LS-E30355 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

BUB1 Antibody Blocking Peptide - LS-E9459 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Bub1 Protein - H00000699-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human Bub1 Protein - H00000699-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Bub1 Peptide - NBP1-77287PEP from Novus Biologicals Category Peptide Prices $149.00 Sizes 50 µg Species Human

Bub1 Peptide - NBP1-76797PEP from Novus Biologicals Category Peptide Prices $149.00 Sizes 50 µg Species Human

Bub1 Peptide - P3049 from Novus Biologicals Category Peptide Species Human

BUB1A-Antibody-N-term-Blocking-peptide - BP5438a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

BUB1-BUB1a-Antibody-C-term-Blocking-peptide - BP8058b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

BUB1A - H00000699-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

BUB1A - H00000699-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

BUB1A - H00000699-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

BUB1A - H00000699-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

BUB1A Control Peptide - AP30171CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

BUB1A Control Peptide - AP30172CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

Bub1 Peptide - 4229P from ProSci Category Peptide Species Human

Bub1 Peptide - 4239P from ProSci Category Peptide Species Human

BUB1 fusion protein - ag4138 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human BUB1 - BUB1-595H from Creative Biomart Category Protein Source Mammalian Cells Species Human

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