SMN2

Gene Symbol	SMN2
Entrez Gene	6607
Alt Symbol	BCD541, C-BCD541, GEMIN1, SMNC, TDRD16B
Species	Human
Gene Type	protein-coding
Description	survival of motor neuron 2, centromeric
Other Description	component of gems 1|gemin-1|survival motor neuron protein|tudor domain containing 16B
Swissprots	A8K0V4 Q16637 Q96J51 Q549U5 Q13119
Accessions	AAC83178 AA029652 AI312583 AK289669 BAF82358 BC000908 AAH00908 BC015308 AAH15308 BC070242 AAH70242 CN272420 DQ185039 DQ891546 ABM82472 DQ894734 ABM85660 EU176225 ABW03676 JQ690861 AFJ92627 JQ690862 AFJ92628 JQ690863 AFJ92629 JQ690864 AFJ92630 JQ690865 AFJ92631 JQ690866 AFJ92632 JQ732167 AFM68923 U21914 AAA64505 XM_011543599 XP_011541901 XM_011543600 XP_011541902 XM_011543601 XP_011541903 XM_011543602 XP_011541904 XM_011543603 XP_011541905 XM_011547356 XP_011545658 XM_011547357 XP_011545659 XM_011547358 XP_011545660 XM_011547359 XP_011545661 XM_011547360 XP_011545662 NM_017411 NP_059107 NM_022875 NP_075013 NM_022876 NP_075014 NM_022877 NP_075015
Function	The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. Ensures the correct splicing of U12 intron-containing genes that may be important for normal motor and proprioceptive neurons development. May also play a role in the metabolism of small nucleol
Subcellular Location	Cytoplasm. Nucleus, gem. Nucleus, Cajal body. Cytoplasmic granule. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250}. Note=Colocalizes with Actn at the Z-line of skeletal muscle (By similarity). Under stress conditions colocalizes with RPP20/POP7 in punctuated cytoplasmic granules. Colocalized and redistributed with ZPR1 from the cytoplasm to nuclear gems (Gemini of coiled bodies) and Cajal bodies. {ECO:0000250}.
Tissue Specificity	Expressed in a wide variety of tissues. Expressed at high levels in brain, kidney and liver, moderate levels in skeletal and cardiac muscle, and low levels in fibroblasts and lymphocytes. Also seen at high levels in spinal cord. Present in osteoclasts and mononuclear cells (at protein level). {ECO:0000269|PubMed:11551898, ECO:0000269|PubMed:9259265}.
Top Pathways	RNA transport

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SMN2 Antibody (2B11-2A9) - H00006607-M01 from Novus Biologicals Prices $359.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 2B11-2A9

SMN2 Antibody - H00006607-B01 from Novus Biologicals Prices $349.00 Sizes 50 µl Host Mouse Clonality Polyclonal

SMN2 Antibody - H00006607-B02P from Novus Biologicals Prices $359.00 Sizes 50 µg Host Mouse Clonality Polyclonal

SMN2 Antibody (1A3-2B9) - H00006607-M02 from Novus Biologicals Prices $359.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 1A3-2B9

SMN2 Antibody - H00006607-B01P from Novus Biologicals Prices $359.00 Sizes 50 µg Host Mouse Clonality Polyclonal

SMN Antibody - H00006607-A02 from Novus Biologicals Prices $269.00 Sizes 50 µl Host Mouse Clonality Polyclonal

SMN2 Antibody - H00006607-D01 from Novus Biologicals Prices $399.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Gemin 1/SMA Polyclonal Antibody - bs-11561R from Bioss Prices $269.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Gemin 1/SMA Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-11561R-A350 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Gemin 1/SMA Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-11561R-A488 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Gemin 1/SMA Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-11561R-A555 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Gemin 1/SMA Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-11561R-A647 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Gemin 1/SMA Polyclonal Antibody, Cy3 Conjugated - bs-11561R-Cy3 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Gemin 1/SMA Polyclonal Antibody, Cy5 Conjugated - bs-11561R-Cy5 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Gemin 1/SMA Polyclonal Antibody, Cy5.5 Conjugated - bs-11561R-Cy5.5 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Gemin 1/SMA Polyclonal Antibody, Cy7 Conjugated - bs-11561R-Cy7 from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Gemin 1/SMA Polyclonal Antibody, FITC Conjugated - bs-11561R-FITC from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Gemin 1/SMA Polyclonal Antibody, Biotin Conjugated - bs-11561R-Biotin from Bioss Prices $349.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Gemin 1/SMA Polyclonal Antibody, HRP Conjugated - bs-11561R-HRP from Bioss Prices $369.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-SMN2 antibody produced in mouse - SAB1409692 from Sigma-Aldrich Prices $347.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Monoclonal Anti-SMN2 antibody produced in mouse - SAB1404381 from Sigma-Aldrich Prices $347.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 1A3-2B9

Monoclonal Anti-SMN2 antibody produced in mouse - SAB1402358 from Sigma-Aldrich Prices $347.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 2B11-2A9

Anti-SMN2 antibody produced in mouse - SAB1409691 from Sigma-Aldrich Prices $347.00 Sizes 50 µg Host Mouse Clonality Polyclonal

SMN2 Antibody - N-terminal region (ARP63346_P050) - ARP63346_P050 from Aviva Systems Biology Prices $289.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

SMN1 Antibody - C-terminal region (OAAB14160) - OAAB14160 from Aviva Systems Biology Prices $289.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

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