SMN2

Gene Symbol	SMN2
Entrez Gene	6607
Alt Symbol	BCD541, C-BCD541, GEMIN1, SMNC, TDRD16B
Species	Human
Gene Type	protein-coding
Description	survival of motor neuron 2, centromeric
Other Description	component of gems 1|gemin-1|survival motor neuron protein|tudor domain containing 16B
Swissprots	A8K0V4 Q16637 Q96J51 Q549U5 Q13119
Accessions	AAC83178 AA029652 AI312583 AK289669 BAF82358 BC000908 AAH00908 BC015308 AAH15308 BC070242 AAH70242 CN272420 DQ185039 DQ891546 ABM82472 DQ894734 ABM85660 EU176225 ABW03676 JQ690861 AFJ92627 JQ690862 AFJ92628 JQ690863 AFJ92629 JQ690864 AFJ92630 JQ690865 AFJ92631 JQ690866 AFJ92632 JQ732167 AFM68923 U21914 AAA64505 XM_011543599 XP_011541901 XM_011543600 XP_011541902 XM_011543601 XP_011541903 XM_011543602 XP_011541904 XM_011543603 XP_011541905 XM_011547356 XP_011545658 XM_011547357 XP_011545659 XM_011547358 XP_011545660 XM_011547359 XP_011545661 XM_011547360 XP_011545662 NM_017411 NP_059107 NM_022875 NP_075013 NM_022876 NP_075014 NM_022877 NP_075015
Function	The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. Ensures the correct splicing of U12 intron-containing genes that may be important for normal motor and proprioceptive neurons development. May also play a role in the metabolism of small nucleol
Subcellular Location	Cytoplasm. Nucleus, gem. Nucleus, Cajal body. Cytoplasmic granule. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250}. Note=Colocalizes with Actn at the Z-line of skeletal muscle (By similarity). Under stress conditions colocalizes with RPP20/POP7 in punctuated cytoplasmic granules. Colocalized and redistributed with ZPR1 from the cytoplasm to nuclear gems (Gemini of coiled bodies) and Cajal bodies. {ECO:0000250}.
Tissue Specificity	Expressed in a wide variety of tissues. Expressed at high levels in brain, kidney and liver, moderate levels in skeletal and cardiac muscle, and low levels in fibroblasts and lymphocytes. Also seen at high levels in spinal cord. Present in osteoclasts and mononuclear cells (at protein level). {ECO:0000269|PubMed:11551898, ECO:0000269|PubMed:9259265}.
Top Pathways	RNA transport

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SMN2 ELISA Kit (Sandwich ELISA) - LS-F7502 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.058 ng/ml Range 0.156-10 ng/ml

Survival Of Motor Neuron 2, Centromeric (SMN2), Human, ELISA Kit - SED498Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.058ng/mL Range 0.156-10ng/mL

Human SMN2 ELISA Kit - KE00027 from Proteintech Group Category ELISA Kit Prices $599.00 Sizes 1 Sensitivity 6 pg/mL Range 62.5pg/mL-4000pg/mL

Human SMN2 ELISA KIT - DEIA8713 from Creative Diagnostics Category ELISA Kit Sensitivity 6 pg/mL

Survival Of Motor Neuron 2, Centromeric (SMN2), ELISA Kit - MBS2023678 from MyBioSource Category ELISA Kit Prices $380.00, $565.00, $765.00, $3,130.00, $5,670.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.058ng/mL. Range 0.156-10ng/mL

ELISA Kit for Survival Of Motor Neuron 2, Centromeric (SMN2) - SED498Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.058ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA's were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Human Survival Of Motor Neuron 2, Centromeric (SMN2) ELISA Kit - EKU07533 from Biomatik Category ELISA Kit Prices $735.00, $3,234.00, $5,880.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 0.058 ng/mL Range 0.156-10 ng/mL

Human TDT(Terminal Deoxynucleotidyl Transferase) ELISA Kit - E-EL-H1755 from Iwai North America Inc. Category ELISA Kit Prices $580.00 Sizes 1 kit Sensitivity 18.75 pg/mLpg/mL Range 31.25~2000 pg/mL

Human DBP (Vitamin D Binding Protein) CLIA Kit - E-CL-H1032 from Iwai North America Inc. Category CLIA Kit Prices $722.50 Sizes 1 kit Sensitivity 2.344ng/mL Range 3.906-250ng/mL

Human SMN2 ELISA Kit - abx153123 from Abbexa Category ELISA Kit Sensitivity 0.058 ng/ml Range 0.156 ng/ml - 10 ng/ml

Survival Of Motor Neuron 2, Centromeric (SMN2), Human, ELISA Kit - DL-SMN2-Hu from ARP American Research Products Category ELISA Kit Prices $655.00 Sizes 96 t Range 0.156-10 ng/mL

Human SMN2 ELISA Kit - abx571109 from Abbexa Category ELISA Kit Sensitivity 0.058 ng/ml Range 0.156 ng/ml - 10 ng/ml

Human SMN2 ELISA Kit - E037029 from Biobool Category ELISA Kit

SMN2 ELISA Kit (Human) (OKDD00533) - OKDD00533 from Aviva Systems Biology Category ELISA Kit Prices $580.00 Sizes 96 wells Sensitivity < 0.058 ng/mL Range 0.156-10 ng/mL

Survival motor neuron protein (SMN1), ELISA Kit - MBS2610193 from MyBioSource Category ELISA Kit Prices $300.00, $475.00, $1,825.00, $3,425.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Survival motor neuron protein, ELISA Kit - MBS2606999 from MyBioSource Category ELISA Kit Prices $315.00, $490.00, $1,825.00, $3,425.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Survival motor neuron protein, ELISA Kit - MBS2607488 from MyBioSource Category ELISA Kit Prices $315.00, $490.00, $1,825.00, $3,425.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Survival motor neuron protein , ELISA Kit - MBS2608184 from MyBioSource Category ELISA Kit Prices $315.00, $490.00, $1,825.00, $3,425.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Survival motor neuron protein, ELISA Kit - MBS2606851 from MyBioSource Category ELISA Kit Prices $315.00, $490.00, $1,825.00, $3,425.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Survival motor neuron protein, ELISA Kit - MBS2607623 from MyBioSource Category ELISA Kit Prices $275.00, $420.00, $1,615.00, $2,880.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Survival of Motor Neuron 2, Centromeric (SMN2), ELISA Kit - MBS9380977 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Survival motor neuron protein, ELISA Kit - MBS2606148 from MyBioSource Category ELISA Kit Prices $315.00, $490.00, $1,825.00, $3,425.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Survival motor neuron protein, ELISA Kit - MBS2603458 from MyBioSource Category ELISA Kit Prices $315.00, $490.00, $1,825.00, $3,425.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Survival motor neuron protein, ELISA Kit - MBS2608439 from MyBioSource Category ELISA Kit Prices $290.00, $450.00, $1,755.00, $3,150.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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