Gene Symbol | Il6 |
---|---|
Entrez Gene | 16193 |
Alt Symbol | Il-6 |
Species | Mouse |
Gene Type | protein-coding |
Description | interleukin 6 |
Other Description | B-cell hybridoma growth factor|interleukin HP-1|interleukin-6 |
Swissprots | P08505 Q8BN26 Q3UCQ0 |
Accessions | AAA39302 AAA68814 CAA35824 EDL37257 EDL37258 P08505 AK089780 AK150440 BAE29562 AK152189 BAE31020 BC132458 AAI32459 BC138766 AAI38767 BC145409 DQ788722 ABG81953 J03783 AAA39301 X06203 CAA29560 X54542 CAA38411 NM_031168 NP_112445 |
Function | Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig- secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation. {ECO:0000269|PubMed:16990136}. |
Subcellular Location | Secreted. |
Top Pathways | TNF signaling pathway, Legionellosis, Herpes simplex infection, PI3K-Akt signaling pathway, African trypanosomiasis |