Gene Symbol | SHQ1 |
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Entrez Gene | 55164 |
Alt Symbol | Shq1p |
Species | Human |
Gene Type | protein-coding |
Description | SHQ1, H/ACA ribonucleoprotein assembly factor |
Other Description | SHQ1 homolog|protein SHQ1 homolog |
Swissprots | Q9NVS8 Q9H7E5 B4DL05 Q6PI26 Q7Z748 Q6MZJ4 |
Accessions | EAW65521 EAW65522 EAW65523 Q6PI26 AK001401 BAA91669 AK092962 AK296789 BAG59367 BC017204 AAH17204 BC017274 AAH17274 BC025270 AAH25270 BC032671 AAH32671 BC039830 AAH39830 BC047879 AAH47879 BX641074 CAE46037 XM_011533894 XP_011532196 XM_011533895 XP_011532197 XM_011533896 XP_011532198 XM_011533897 XP_011532199 XM_011533898 XP_011532200 XM_011533899 XP_011532201 NM_018130 NP_060600 |
Function | Required for the quantitative accumulation of H/ACA ribonucleoproteins (RNPs), including telomerase, probably through the stabilization of DKC1, from the time of its synthesis until its association with NOP10, NHP2, and NAF1 at the nascent H/ACA RNA. {ECO:0000269|PubMed:19383767}. |
Subcellular Location | Cytoplasm, cytosol {ECO:0000269|PubMed:19383767}. Nucleus, nucleoplasm {ECO:0000269|PubMed:19383767}. Note=May at least partially shuttle between cytosol and nucleoplasm. In the nucleoplasm, exhibits a granular pattern, but is excluded from nucleoli and Cajal bodies. Absent from most H/ACA-box RNA transcription sites. |
SHQ1 CRISPR/Cas9 KO Plasmid (h) - sc-408251 from Santa Cruz Biotechnology
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SHQ1 HDR Plasmid (h) - sc-408251-HDR from Santa Cruz Biotechnology
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SHQ1 Double Nickase Plasmid (h) - sc-408251-NIC from Santa Cruz Biotechnology
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SHQ1 Double Nickase Plasmid (h2) - sc-408251-NIC-2 from Santa Cruz Biotechnology
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SHQ1 CRISPR Activation Plasmid (h) - sc-408251-ACT from Santa Cruz Biotechnology
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SHQ1 CRISPR Activation Plasmid (h2) - sc-408251-ACT-2 from Santa Cruz Biotechnology
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SHQ1 Lentiviral Activation Particles (h) - sc-408251-LAC from Santa Cruz Biotechnology
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SHQ1 Lentiviral Activation Particles (h2) - sc-408251-LAC-2 from Santa Cruz Biotechnology
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SHQ1 siRNA (h) - sc-78189 from Santa Cruz Biotechnology
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SHQ1 shRNA Plasmid (h) - sc-78189-SH from Santa Cruz Biotechnology
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SHQ1 shRNA (h) Lentiviral Particles - sc-78189-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU110831 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19314 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19314 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07705 from Sigma-Aldrich
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SHQ1 siRNA (Human) - CRJ0518 from Cohesion Biosciences
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SHQ1 - MBS8216580 from MyBioSource
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shRNA set against Human SHQ1 (NM_018130.2) - SHH407252 from Creative biogene
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shRNA set against Human SHQ1(NM_018130.2) - SHR224660 from Creative biogene
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SHQ1 shRNA Plasmid (Human) - CHJ0518 from Cohesion Biosciences
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SHQ1 miRNA 3'UTR clone - MiUTR1H-09385 from Creative biogene
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